TY - JOUR
T1 - Computational investigation of subject-specific cerebrospinal fluid flow in the third ventricle and aqueduct of Sylvius
AU - Kurtcuoglu, Vartan
AU - Soellinger, Michaela
AU - Summers, Paul
AU - Boomsma, Kevin
AU - Poulikakos, Dimos
AU - Boesiger, Peter
AU - Ventikos, Yiannis
N1 - Funding Information:
The financial support of the ETH Zurich Research Commission has made this research possible and is kindly acknowledged.
PY - 2007
Y1 - 2007
N2 - The cerebrospinal fluid flow in the third ventricle of the brain and the aqueduct of Sylvius was studied using computational fluid dynamics (CFD) based on subject-specific boundary conditions derived from magnetic resonance imaging (MRI) scans. The flow domain geometry was reconstructed from anatomical MRI scans by manual image segmentation. The movement of the domain boundary was derived from MRI brain motion scans. Velocimetric MRI scans were used to reconstruct the velocity field at the inferior end of the aqueduct of Sylvius based on the theory of pulsatile flow in pipes. A constant pressure boundary condition was assigned at the foramina of Monro. Three main flow features were observed: a fluid jet emerging from the aqueduct of Sylvius, a moderately mobile recirculation zone above the jet and a mobile recirculation below the jet. The flow in the entire domain was laminar with a maximum Reynolds number of 340 in the aqueduct. The findings demonstrate that by combining MRI scans and CFD simulations, subject-specific detailed quantitative information of the flow field in the third ventricle and the aqueduct of Sylvius can be obtained.
AB - The cerebrospinal fluid flow in the third ventricle of the brain and the aqueduct of Sylvius was studied using computational fluid dynamics (CFD) based on subject-specific boundary conditions derived from magnetic resonance imaging (MRI) scans. The flow domain geometry was reconstructed from anatomical MRI scans by manual image segmentation. The movement of the domain boundary was derived from MRI brain motion scans. Velocimetric MRI scans were used to reconstruct the velocity field at the inferior end of the aqueduct of Sylvius based on the theory of pulsatile flow in pipes. A constant pressure boundary condition was assigned at the foramina of Monro. Three main flow features were observed: a fluid jet emerging from the aqueduct of Sylvius, a moderately mobile recirculation zone above the jet and a mobile recirculation below the jet. The flow in the entire domain was laminar with a maximum Reynolds number of 340 in the aqueduct. The findings demonstrate that by combining MRI scans and CFD simulations, subject-specific detailed quantitative information of the flow field in the third ventricle and the aqueduct of Sylvius can be obtained.
KW - Cerebrospinal fluid
KW - Computational fluid dynamics
KW - Magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=33947592243&partnerID=8YFLogxK
U2 - 10.1016/j.jbiomech.2006.05.031
DO - 10.1016/j.jbiomech.2006.05.031
M3 - Article
C2 - 16904117
AN - SCOPUS:33947592243
SN - 0021-9290
VL - 40
SP - 1235
EP - 1245
JO - Journal of Biomechanics
JF - Journal of Biomechanics
IS - 6
ER -