Compromised telomeric heterochromatin promotes ALTernative lengthening of telomeres

Hsiao P.J. Voon, Philippe Collas, Lee H. Wong

Research output: Contribution to journalReview ArticleOtherpeer-review

11 Citations (Scopus)

Abstract

Alternative lengthening of telomeres (ALT) is an enigmatic process that allows certain cancers to maintain telomeres in the absence of telomerase. ALT cancers are frequently defective for ATRX/DAXX, a chaperone complex that deposits histone variant H3.3 at telomeres. We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX) prime ALT activation by disrupting telomeric heterochromatin.

Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalTrends In Cancer
Volume2
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016

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