Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate

Robbin Ralf Vernooij; Tanmaya Joshi; Evyenia Shaili; Manja Kubeil; Dominique R T Appadoo; Ekaterina I. Izgorodina; Bimbil Graham; Peter J. Sadler; Bayden Wood; Leone Spiccia

doi:10.1021/acs.inorgchem.6b00476

Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N₃)₂(OH)₂(py)₂], a Pt(IV) diazido anticancer prodrug candidate

Robbin Ralf Vernooij, Tanmaya Joshi, Evyenia Shaili, Manja Kubeil, Dominique R T Appadoo, Ekaterina I. Izgorodina, Bimbil Graham, Peter J. Sadler, Bayden Wood, Leone Spiccia

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26 Citations (Scopus)

Abstract

We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N₃)₂(OH)₂(py)₂] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N₃)₂(py)₂] (C2) and trans-[PtCl₂(py)₂] (C3)). Distinct IR-and Raman-Active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid-and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.

Original language	English
Pages (from-to)	5983-5992
Number of pages	10
Journal	Inorganic Chemistry
Volume	55
Issue number	12
DOIs	https://doi.org/10.1021/acs.inorgchem.6b00476
Publication status	Published - 20 Jun 2016

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Vernooij, R. R., Joshi, T., Shaili, E., Kubeil, M., Appadoo, D. R. T., Izgorodina, E. I., Graham, B., Sadler, P. J., Wood, B., & Spiccia, L. (2016). Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N₃)₂(OH)₂(py)₂], a Pt(IV) diazido anticancer prodrug candidate. Inorganic Chemistry, 55(12), 5983-5992. https://doi.org/10.1021/acs.inorgchem.6b00476

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title = "Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate",

abstract = "We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR-and Raman-Active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid-and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.",

author = "Vernooij, \{Robbin Ralf\} and Tanmaya Joshi and Evyenia Shaili and Manja Kubeil and Appadoo, \{Dominique R T\} and Izgorodina, \{Ekaterina I.\} and Bimbil Graham and Sadler, \{Peter J.\} and Bayden Wood and Leone Spiccia",

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AU - Vernooij, Robbin Ralf

AU - Joshi, Tanmaya

AU - Shaili, Evyenia

AU - Kubeil, Manja

AU - Appadoo, Dominique R T

AU - Izgorodina, Ekaterina I.

AU - Graham, Bimbil

AU - Sadler, Peter J.

AU - Wood, Bayden

AU - Spiccia, Leone

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N2 - We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR-and Raman-Active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid-and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.

AB - We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR-and Raman-Active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid-and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.

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Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N₃)₂(OH)₂(py)₂], a Pt(IV) diazido anticancer prodrug candidate

Abstract

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Expanding the molecular tool set for structural studies of proteins and their complexes

Functionalized Nanomaterials for Application as Multimodal Cancer Imaging Agents

Coupling biophotonic modalities with machine based recognition systems for disease diagnosis

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Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate

Abstract

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Projects

Expanding the molecular tool set for structural studies of proteins and their complexes

Functionalized Nanomaterials for Application as Multimodal Cancer Imaging Agents

Coupling biophotonic modalities with machine based recognition systems for disease diagnosis

Cite this

Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N₃)₂(OH)₂(py)₂], a Pt(IV) diazido anticancer prodrug candidate