Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate

Robbin Ralf Vernooij, Tanmaya Joshi, Evyenia Shaili, Manja Kubeil, Dominique R T Appadoo, Ekaterina I. Izgorodina, Bimbil Graham, Peter J. Sadler, Bayden Wood, Leone Spiccia

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Abstract

We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR-and Raman-Active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid-and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.

Original languageEnglish
Pages (from-to)5983-5992
Number of pages10
JournalInorganic Chemistry
Volume55
Issue number12
DOIs
Publication statusPublished - 20 Jun 2016

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