Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate

Robbin Ralf Vernooij, Tanmaya Joshi, Evyenia Shaili, Manja Kubeil, Dominique R T Appadoo, Ekaterina I. Izgorodina, Bimbil Graham, Peter J. Sadler, Bayden Wood, Leone Spiccia

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR-and Raman-Active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid-and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.

Original languageEnglish
Pages (from-to)5983-5992
Number of pages10
JournalInorganic Chemistry
Volume55
Issue number12
DOIs
Publication statusPublished - 20 Jun 2016

Cite this

Vernooij, Robbin Ralf ; Joshi, Tanmaya ; Shaili, Evyenia ; Kubeil, Manja ; Appadoo, Dominique R T ; Izgorodina, Ekaterina I. ; Graham, Bimbil ; Sadler, Peter J. ; Wood, Bayden ; Spiccia, Leone. / Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate. In: Inorganic Chemistry. 2016 ; Vol. 55, No. 12. pp. 5983-5992.
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abstract = "We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR-and Raman-Active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid-and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.",
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Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate. / Vernooij, Robbin Ralf; Joshi, Tanmaya; Shaili, Evyenia; Kubeil, Manja; Appadoo, Dominique R T; Izgorodina, Ekaterina I.; Graham, Bimbil; Sadler, Peter J.; Wood, Bayden; Spiccia, Leone.

In: Inorganic Chemistry, Vol. 55, No. 12, 20.06.2016, p. 5983-5992.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Vernooij, Robbin Ralf

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AU - Shaili, Evyenia

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AU - Appadoo, Dominique R T

AU - Izgorodina, Ekaterina I.

AU - Graham, Bimbil

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AU - Wood, Bayden

AU - Spiccia, Leone

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