Projects per year
Abstract
We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR-and Raman-Active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid-and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.
Original language | English |
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Pages (from-to) | 5983-5992 |
Number of pages | 10 |
Journal | Inorganic Chemistry |
Volume | 55 |
Issue number | 12 |
DOIs | |
Publication status | Published - 20 Jun 2016 |
Projects
- 3 Finished
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Expanding the molecular tool set for structural studies of proteins and their complexes
Graham, B.
Australian Research Council (ARC)
1/01/14 → 31/12/17
Project: Research
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Functionalized Nanomaterials for Application as Multimodal Cancer Imaging Agents
Spiccia, L.
Australian Research Council (ARC), Monash University
3/01/13 → 1/01/17
Project: Research
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Coupling biophotonic modalities with machine based recognition systems for disease diagnosis
Australian Research Council (ARC)
31/12/12 → 31/12/17
Project: Research