Complex diseases and co-morbidities

Polycystic ovary syndrome and type 2 diabetes mellitus

Raymond J. Rodgers, Jodie C. Avery, Vivienne M. Moore, Michael J. Davies, Ricardo Azziz, Elisabet Stener-Victorin, Lisa J. Moran, Sarah A. Robertson, Nigel K. Stepto, Robert J. Norman, Helena J. Teede

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Objective Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8–13% of women of reproductive age. With a four-fold increased risk of type 2 diabetes (DM2), the Population Attributable Risk of DM2 that could be avoided if PCOS were eliminated is a substantial 19–28% of women of reproductive age. To determine the extent to which PCOS is an important consideration in diabetes development, we examined publications, funding, guidelines and predictors of risk of developing DM2. Results We found that the topic of PCOS appeared in specialist diabetes journals at only 10% the rate seen in endocrinology journals – about 1 in 500 articles. We found research funding to be substantially less than for diabetes and found that diabetes guidelines and predictive tools for DM2 risk mostly ignore PCOS. This is surprising since insulin resistance in women with PCOS has a different aetiology and additionally women with PCOS are at increased risk of becoming overweight or obese – high risk factors for DM2. Conclusions We consider the causes of these concerning anomalies and discuss current activities to address the co-morbidities of PCOS, including the recent development of international guidelines, an international PCOS awareness program and potentially changing the name of PCOS to better reflect its metabolic consequences.

Original languageEnglish
Pages (from-to)R71-R75
Number of pages5
JournalEndocrine Connections
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Diabetes
  • PCOS

Cite this

Rodgers, R. J., Avery, J. C., Moore, V. M., Davies, M. J., Azziz, R., Stener-Victorin, E., ... Teede, H. J. (2019). Complex diseases and co-morbidities: Polycystic ovary syndrome and type 2 diabetes mellitus. Endocrine Connections, 8(3), R71-R75. https://doi.org/10.1530/EC-18-0502
Rodgers, Raymond J. ; Avery, Jodie C. ; Moore, Vivienne M. ; Davies, Michael J. ; Azziz, Ricardo ; Stener-Victorin, Elisabet ; Moran, Lisa J. ; Robertson, Sarah A. ; Stepto, Nigel K. ; Norman, Robert J. ; Teede, Helena J. / Complex diseases and co-morbidities : Polycystic ovary syndrome and type 2 diabetes mellitus. In: Endocrine Connections. 2019 ; Vol. 8, No. 3. pp. R71-R75.
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abstract = "Objective Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8–13{\%} of women of reproductive age. With a four-fold increased risk of type 2 diabetes (DM2), the Population Attributable Risk of DM2 that could be avoided if PCOS were eliminated is a substantial 19–28{\%} of women of reproductive age. To determine the extent to which PCOS is an important consideration in diabetes development, we examined publications, funding, guidelines and predictors of risk of developing DM2. Results We found that the topic of PCOS appeared in specialist diabetes journals at only 10{\%} the rate seen in endocrinology journals – about 1 in 500 articles. We found research funding to be substantially less than for diabetes and found that diabetes guidelines and predictive tools for DM2 risk mostly ignore PCOS. This is surprising since insulin resistance in women with PCOS has a different aetiology and additionally women with PCOS are at increased risk of becoming overweight or obese – high risk factors for DM2. Conclusions We consider the causes of these concerning anomalies and discuss current activities to address the co-morbidities of PCOS, including the recent development of international guidelines, an international PCOS awareness program and potentially changing the name of PCOS to better reflect its metabolic consequences.",
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Rodgers, RJ, Avery, JC, Moore, VM, Davies, MJ, Azziz, R, Stener-Victorin, E, Moran, LJ, Robertson, SA, Stepto, NK, Norman, RJ & Teede, HJ 2019, 'Complex diseases and co-morbidities: Polycystic ovary syndrome and type 2 diabetes mellitus', Endocrine Connections, vol. 8, no. 3, pp. R71-R75. https://doi.org/10.1530/EC-18-0502

Complex diseases and co-morbidities : Polycystic ovary syndrome and type 2 diabetes mellitus. / Rodgers, Raymond J.; Avery, Jodie C.; Moore, Vivienne M.; Davies, Michael J.; Azziz, Ricardo; Stener-Victorin, Elisabet; Moran, Lisa J.; Robertson, Sarah A.; Stepto, Nigel K.; Norman, Robert J.; Teede, Helena J.

In: Endocrine Connections, Vol. 8, No. 3, 03.2019, p. R71-R75.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Complex diseases and co-morbidities

T2 - Polycystic ovary syndrome and type 2 diabetes mellitus

AU - Rodgers, Raymond J.

AU - Avery, Jodie C.

AU - Moore, Vivienne M.

AU - Davies, Michael J.

AU - Azziz, Ricardo

AU - Stener-Victorin, Elisabet

AU - Moran, Lisa J.

AU - Robertson, Sarah A.

AU - Stepto, Nigel K.

AU - Norman, Robert J.

AU - Teede, Helena J.

PY - 2019/3

Y1 - 2019/3

N2 - Objective Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8–13% of women of reproductive age. With a four-fold increased risk of type 2 diabetes (DM2), the Population Attributable Risk of DM2 that could be avoided if PCOS were eliminated is a substantial 19–28% of women of reproductive age. To determine the extent to which PCOS is an important consideration in diabetes development, we examined publications, funding, guidelines and predictors of risk of developing DM2. Results We found that the topic of PCOS appeared in specialist diabetes journals at only 10% the rate seen in endocrinology journals – about 1 in 500 articles. We found research funding to be substantially less than for diabetes and found that diabetes guidelines and predictive tools for DM2 risk mostly ignore PCOS. This is surprising since insulin resistance in women with PCOS has a different aetiology and additionally women with PCOS are at increased risk of becoming overweight or obese – high risk factors for DM2. Conclusions We consider the causes of these concerning anomalies and discuss current activities to address the co-morbidities of PCOS, including the recent development of international guidelines, an international PCOS awareness program and potentially changing the name of PCOS to better reflect its metabolic consequences.

AB - Objective Many complex diseases exhibit co-morbidities often requiring management by more than one health specialist. We examined cross-speciality issues that ultimately affect the health and wellbeing of patients with polycystic ovary syndrome (PCOS). PCOS was originally described as a reproductive condition but is now recognised to also be a metabolic and psychological condition affecting 8–13% of women of reproductive age. With a four-fold increased risk of type 2 diabetes (DM2), the Population Attributable Risk of DM2 that could be avoided if PCOS were eliminated is a substantial 19–28% of women of reproductive age. To determine the extent to which PCOS is an important consideration in diabetes development, we examined publications, funding, guidelines and predictors of risk of developing DM2. Results We found that the topic of PCOS appeared in specialist diabetes journals at only 10% the rate seen in endocrinology journals – about 1 in 500 articles. We found research funding to be substantially less than for diabetes and found that diabetes guidelines and predictive tools for DM2 risk mostly ignore PCOS. This is surprising since insulin resistance in women with PCOS has a different aetiology and additionally women with PCOS are at increased risk of becoming overweight or obese – high risk factors for DM2. Conclusions We consider the causes of these concerning anomalies and discuss current activities to address the co-morbidities of PCOS, including the recent development of international guidelines, an international PCOS awareness program and potentially changing the name of PCOS to better reflect its metabolic consequences.

KW - Diabetes

KW - PCOS

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JF - Endocrine Connections

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Rodgers RJ, Avery JC, Moore VM, Davies MJ, Azziz R, Stener-Victorin E et al. Complex diseases and co-morbidities: Polycystic ovary syndrome and type 2 diabetes mellitus. Endocrine Connections. 2019 Mar;8(3):R71-R75. https://doi.org/10.1530/EC-18-0502