Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis

Zhi Q. Tan; Ean H. Ooi; Yeong S. Chiew; Ji J. Foo; Eddie Y.K. Ng; Ean T. Ooi

doi:10.1007/978-981-97-1920-4_2

Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis

Zhi Q. Tan, Ean H. Ooi, Yeong S. Chiew, Ji J. Foo, Eddie Y.K. Ng, Ean T. Ooi

Malaysia School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

Abstract

Sonothrombolysis is a technique that uses ultrasound and microbubbles to break down the clot. Despite its potential, it remains challenging to identify the right combination of ultrasound and microbubble properties that can lead to the best treatment of clots. To address this, a finite element model of a microbubble surrounded by blood and is next to a clot was developed to investigate the jetting behaviour of microbubbles using different combinations of microbubble radius and ultrasound pressure. Numerical results indicated a strong competing effect between jet velocity, jet width, and distance travelled by the bubble, which is likely due to the confining effect of clot. This effect can be detrimental to sonothrombolysis, especially when using smaller microbubbles. In addition, a higher ultrasound pressure was found to affect the jetting behaviour in a similar way as using a larger microbubble. The ability of the model to visualize the bubble behaviour in the fast temporal and the small spatial scale opens numerous opportunities for the optimisation and clinical translation of sonothrombolysis.

Original language	English
Title of host publication	Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs - APSAO
Subtitle of host publication	Making Breakthrough via Multidisciplinary Approach
Editors	Mohd Jamil Mohamed Mokhtarudin, Azam Ahmad Bakir, Andrew Stephens, Nadiah Sulaiman
Publisher	Springer
Pages	11-18
Number of pages	8
ISBN (Print)	9789819721108
DOIs	https://doi.org/10.1007/978-981-97-1920-4_2
Publication status	Published - 2024
Event	Annual Congress of the Asia-Pacific Society for Artificial Organs 2023 - University of Malaya. PAUM Clubhouse, Kuala Lumpur, Malaysia Duration: 25 Sept 2023 → 26 Sept 2023 Conference number: 7th https://link.springer.com/book/10.1007/978-981-97-1920-4 (Published Proceedings) https://asiancardiac.com/ap23a.html (Website)

Publication series

Name	Lecture Notes in Bioengineering
ISSN (Print)	2195-271X
ISSN (Electronic)	2195-2728

Conference

Conference	Annual Congress of the Asia-Pacific Society for Artificial Organs 2023
Abbreviated title	APSAO 2023
Country/Territory	Malaysia
City	Kuala Lumpur
Period	25/09/23 → 26/09/23
Internet address	https://link.springer.com/book/10.1007/978-981-97-1920-4 (Published Proceedings) https://asiancardiac.com/ap23a.html (Website)

Keywords

Bubble dynamics
Microjet
Sonothrombolysis
Ultrasound

Access to Document

10.1007/978-981-97-1920-4_2

Cite this

Tan, Z. Q., Ooi, E. H., Chiew, Y. S., Foo, J. J., Ng, E. Y. K., & Ooi, E. T. (2024). Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis. In M. J. Mohamed Mokhtarudin, A. Ahmad Bakir, A. Stephens, & N. Sulaiman (Eds.), Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs - APSAO: Making Breakthrough via Multidisciplinary Approach (pp. 11-18). (Lecture Notes in Bioengineering). Springer. https://doi.org/10.1007/978-981-97-1920-4_2

Tan, Zhi Q. ; Ooi, Ean H. ; Chiew, Yeong S. et al. / Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis. Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs - APSAO: Making Breakthrough via Multidisciplinary Approach. editor / Mohd Jamil Mohamed Mokhtarudin ; Azam Ahmad Bakir ; Andrew Stephens ; Nadiah Sulaiman. Springer, 2024. pp. 11-18 (Lecture Notes in Bioengineering).

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title = "Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis",

abstract = "Sonothrombolysis is a technique that uses ultrasound and microbubbles to break down the clot. Despite its potential, it remains challenging to identify the right combination of ultrasound and microbubble properties that can lead to the best treatment of clots. To address this, a finite element model of a microbubble surrounded by blood and is next to a clot was developed to investigate the jetting behaviour of microbubbles using different combinations of microbubble radius and ultrasound pressure. Numerical results indicated a strong competing effect between jet velocity, jet width, and distance travelled by the bubble, which is likely due to the confining effect of clot. This effect can be detrimental to sonothrombolysis, especially when using smaller microbubbles. In addition, a higher ultrasound pressure was found to affect the jetting behaviour in a similar way as using a larger microbubble. The ability of the model to visualize the bubble behaviour in the fast temporal and the small spatial scale opens numerous opportunities for the optimisation and clinical translation of sonothrombolysis.",

keywords = "Bubble dynamics, Microjet, Sonothrombolysis, Ultrasound",

author = "Tan, {Zhi Q.} and Ooi, {Ean H.} and Chiew, {Yeong S.} and Foo, {Ji J.} and Ng, {Eddie Y.K.} and Ooi, {Ean T.}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.; Annual Congress of the Asia-Pacific Society for Artificial Organs 2023, APSAO 2023 ; Conference date: 25-09-2023 Through 26-09-2023",

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booktitle = "Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs - APSAO",

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Tan, ZQ, Ooi, EH , Chiew, YS , Foo, JJ, Ng, EYK & Ooi, ET 2024, Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis. in MJ Mohamed Mokhtarudin, A Ahmad Bakir, A Stephens & N Sulaiman (eds), Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs - APSAO: Making Breakthrough via Multidisciplinary Approach. Lecture Notes in Bioengineering, Springer, pp. 11-18, Annual Congress of the Asia-Pacific Society for Artificial Organs 2023, Kuala Lumpur, Malaysia, 25/09/23. https://doi.org/10.1007/978-981-97-1920-4_2

Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis. / Tan, Zhi Q.; Ooi, Ean H.; Chiew, Yeong S. et al.
Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs - APSAO: Making Breakthrough via Multidisciplinary Approach. ed. / Mohd Jamil Mohamed Mokhtarudin; Azam Ahmad Bakir; Andrew Stephens; Nadiah Sulaiman. Springer, 2024. p. 11-18 (Lecture Notes in Bioengineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

TY - GEN

T1 - Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis

AU - Tan, Zhi Q.

AU - Ooi, Ean H.

AU - Chiew, Yeong S.

AU - Foo, Ji J.

AU - Ng, Eddie Y.K.

AU - Ooi, Ean T.

N1 - Conference code: 7th

PY - 2024

Y1 - 2024

N2 - Sonothrombolysis is a technique that uses ultrasound and microbubbles to break down the clot. Despite its potential, it remains challenging to identify the right combination of ultrasound and microbubble properties that can lead to the best treatment of clots. To address this, a finite element model of a microbubble surrounded by blood and is next to a clot was developed to investigate the jetting behaviour of microbubbles using different combinations of microbubble radius and ultrasound pressure. Numerical results indicated a strong competing effect between jet velocity, jet width, and distance travelled by the bubble, which is likely due to the confining effect of clot. This effect can be detrimental to sonothrombolysis, especially when using smaller microbubbles. In addition, a higher ultrasound pressure was found to affect the jetting behaviour in a similar way as using a larger microbubble. The ability of the model to visualize the bubble behaviour in the fast temporal and the small spatial scale opens numerous opportunities for the optimisation and clinical translation of sonothrombolysis.

AB - Sonothrombolysis is a technique that uses ultrasound and microbubbles to break down the clot. Despite its potential, it remains challenging to identify the right combination of ultrasound and microbubble properties that can lead to the best treatment of clots. To address this, a finite element model of a microbubble surrounded by blood and is next to a clot was developed to investigate the jetting behaviour of microbubbles using different combinations of microbubble radius and ultrasound pressure. Numerical results indicated a strong competing effect between jet velocity, jet width, and distance travelled by the bubble, which is likely due to the confining effect of clot. This effect can be detrimental to sonothrombolysis, especially when using smaller microbubbles. In addition, a higher ultrasound pressure was found to affect the jetting behaviour in a similar way as using a larger microbubble. The ability of the model to visualize the bubble behaviour in the fast temporal and the small spatial scale opens numerous opportunities for the optimisation and clinical translation of sonothrombolysis.

KW - Bubble dynamics

KW - Microjet

KW - Sonothrombolysis

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85207674462&partnerID=8YFLogxK

U2 - 10.1007/978-981-97-1920-4_2

DO - 10.1007/978-981-97-1920-4_2

M3 - Conference Paper

AN - SCOPUS:85207674462

SN - 9789819721108

T3 - Lecture Notes in Bioengineering

SP - 11

EP - 18

BT - Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs - APSAO

A2 - Mohamed Mokhtarudin, Mohd Jamil

A2 - Ahmad Bakir, Azam

A2 - Stephens, Andrew

A2 - Sulaiman, Nadiah

PB - Springer

T2 - Annual Congress of the Asia-Pacific Society for Artificial Organs 2023

Y2 - 25 September 2023 through 26 September 2023

ER -

Tan ZQ, Ooi EH , Chiew YS , Foo JJ, Ng EYK, Ooi ET. Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis. In Mohamed Mokhtarudin MJ, Ahmad Bakir A, Stephens A, Sulaiman N, editors, Proceedings of the Annual Congress of the Asia-Pacific Society for Artificial Organs - APSAO: Making Breakthrough via Multidisciplinary Approach. Springer. 2024. p. 11-18. (Lecture Notes in Bioengineering). doi: 10.1007/978-981-97-1920-4_2

Competing Effect of Jetting During Microbubble-Mediated Sonothrombolysis

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Keywords

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