Compensatory recruitment after sleep deprivation and the relationship with performance

Sean P.A. Drummond, M. J. Meloy, Matthew A. Yanagi, Henry J. Orff, Gregory G. Brown

Research output: Contribution to journalArticleResearchpeer-review

128 Citations (Scopus)

Abstract

This study examined the effects of total sleep deprivation (TSD) on cerebral responses to a verbal learning task with two levels of word difficulty. A total of 32 subjects were studied with functional magnetic resonance imaging (FMRI) after normal sleep and following 36 h of TSD. Cerebral responses to EASY words were identical on both nights, but several brain regions showed increased activation to HARD words following TSD compared with following a normal night of sleep (NORM). These regions included bilateral inferior frontal gyrus, bilateral dorsolateral prefrontal cortex, and bilateral inferior parietal lobe. Better free recall performance on the HARD words after TSD was related to increased cerebral responses within the left inferior and superior parietal lobes and left inferior frontal gyrus. Recall was negatively related to activation within the right inferior frontal gyrus. Overall, the findings support the predictions of the compensatory recruitment hypothesis that task demands influence both the likelihood and location of increased cerebral activation during task performance following TSD, and refine that hypothesis by identifying a specific task demand that plays a role. The performance relationships suggest increased activation may be both beneficial (compensatory) and interfere with task performance, depending on the brain regions involved.

Original languageEnglish
Pages (from-to)211-223
Number of pages13
JournalPsychiatry Research: Neuroimaging
Volume140
Issue number3
DOIs
Publication statusPublished - 30 Dec 2005
Externally publishedYes

Keywords

  • Cognitive performance
  • Functional magnetic resonance imaging
  • Parietal lobes
  • Prefrontal cortex
  • Verbal learning

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