Comparison of two-dimensional synthesized mammograms versus original digital mammograms: a quantitative assessment

Maxine Tan, Mundher Al-Shabi, Wai Yee Chan, Leya Thomas, Kartini Rahmat, Kwan Hoong Ng

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    This study objectively evaluates the similarity between standard full-field digital mammograms and two-dimensional synthesized digital mammograms (2DSM) in a cohort of women undergoing mammography. Under an institutional review board–approved data collection protocol, we retrospectively analyzed 407 women with digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) examinations performed from September 1, 2014, through February 29, 2016. Both FFDM and 2DSM images were used for the analysis, and 3216 available craniocaudal (CC) and mediolateral oblique (MLO) view mammograms altogether were included in the dataset. We analyzed the mammograms using a fully automated algorithm that computes 152 structural similarity, texture, and mammographic density–based features. We trained and developed two different global mammographic image feature analysis–based breast cancer detection schemes for 2DSM and FFDM images, respectively. The highest structural similarity features were obtained on the coarse Weber Local Descriptor differential excitation texture feature component computed on the CC view images (0.8770) and MLO view images (0.8889). Although the coarse structures are similar, the global mammographic image feature–based cancer detection scheme trained on 2DSM images outperformed the corresponding scheme trained on FFDM images, with area under a receiver operating characteristic curve (AUC) = 0.878 ± 0.034 and 0.756 ± 0.052, respectively. Consequently, further investigation is required to examine whether DBT can replace FFDM as a standalone technique, especially for the development of automated objective-based methods. Graphical abstract: [Figure not available: see fulltext.]

    Original languageEnglish
    Pages (from-to)355-367
    Number of pages13
    JournalMedical & Biological Engineering & Computing
    Issue number2
    Publication statusPublished - Feb 2021


    • Algorithms
    • Breast density
    • Mammography
    • Structural similarity
    • Two-dimensional synthesized mammograms

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