Comparison of total body chlorine, potassium, and water measurements in children with cystic fibrosis

Daniel J. Borovnicar, Daniel B. Stroud, Julie E. Bines, Ric H.M. Haslam, Boyd J.G. Strauss

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Background: Symptoms of cystic fibrosis (CF) may limit the utility of total body chlorine (TBCl) and total body potassium (TBK) measurements for assessing body fluid compartments of children. Objective: This study assessed relations among independent measurements of TBCl. TBK, and total body water (TBW) in children with CF. Design: We compared cross-sectional measurements of TBCl by in vivo neutron activation analysis, TBK by whole-body counting of 40K. TBW by D2O dilution [TBW(D2O)], and TBW from TBCl and TBK [TBW(Cl + K)] in 19 prepubertal children (13 boys) aged 7.6-12.5 y who had mild symptoms of CF. Body-composition measurements were compared with data from previous studies of healthy children. Results: Subjects with CF had deficits in TBCl, TBK, TBW, and body weight compared with control reference data (P < 0.05). The ratios (TBCl + TBK)/TBW and TBCl/TBK were not significantly different from control reference values, and plasma chlorine and potassium concentrations were within control reference ranges. The sum of TBCl and TBK correlated with TBW(D2O) (r2 = 0.79, P < 0.001), and TBW(Cl + K) correlated with TBW(D2O) (r2 = 0.78, P < 0.001). TBW(Cl + K) was similar to TBW(D2O) (x̄ ± SEM: 19.0 ± 0.5 compared with 19.4 ± 0.5 L; NS). Conclusions: Prepubertal children with mild symptoms of CF can develop deficits in TBCl. TBK, and TBW that reflect chronic energy malnutrition. Mild symptoms of CF do not appear to affect normal relations among TBCl, TBK, and TBW. Measurements of TBCl and TBK may be used to assess body fluid compartments in these patients.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume71
Issue number1
Publication statusPublished - 1 Jan 2000

Keywords

  • Body composition
  • Cystic fibrosis
  • Extracellular water
  • Intracellular water
  • Prepubertal children
  • Total body chlorine
  • Total body potassium
  • Total body water

Cite this

Borovnicar, Daniel J. ; Stroud, Daniel B. ; Bines, Julie E. ; Haslam, Ric H.M. ; Strauss, Boyd J.G. / Comparison of total body chlorine, potassium, and water measurements in children with cystic fibrosis. In: American Journal of Clinical Nutrition. 2000 ; Vol. 71, No. 1. pp. 36-43.
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abstract = "Background: Symptoms of cystic fibrosis (CF) may limit the utility of total body chlorine (TBCl) and total body potassium (TBK) measurements for assessing body fluid compartments of children. Objective: This study assessed relations among independent measurements of TBCl. TBK, and total body water (TBW) in children with CF. Design: We compared cross-sectional measurements of TBCl by in vivo neutron activation analysis, TBK by whole-body counting of 40K. TBW by D2O dilution [TBW(D2O)], and TBW from TBCl and TBK [TBW(Cl + K)] in 19 prepubertal children (13 boys) aged 7.6-12.5 y who had mild symptoms of CF. Body-composition measurements were compared with data from previous studies of healthy children. Results: Subjects with CF had deficits in TBCl, TBK, TBW, and body weight compared with control reference data (P < 0.05). The ratios (TBCl + TBK)/TBW and TBCl/TBK were not significantly different from control reference values, and plasma chlorine and potassium concentrations were within control reference ranges. The sum of TBCl and TBK correlated with TBW(D2O) (r2 = 0.79, P < 0.001), and TBW(Cl + K) correlated with TBW(D2O) (r2 = 0.78, P < 0.001). TBW(Cl + K) was similar to TBW(D2O) (x̄ ± SEM: 19.0 ± 0.5 compared with 19.4 ± 0.5 L; NS). Conclusions: Prepubertal children with mild symptoms of CF can develop deficits in TBCl. TBK, and TBW that reflect chronic energy malnutrition. Mild symptoms of CF do not appear to affect normal relations among TBCl, TBK, and TBW. Measurements of TBCl and TBK may be used to assess body fluid compartments in these patients.",
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Comparison of total body chlorine, potassium, and water measurements in children with cystic fibrosis. / Borovnicar, Daniel J.; Stroud, Daniel B.; Bines, Julie E.; Haslam, Ric H.M.; Strauss, Boyd J.G.

In: American Journal of Clinical Nutrition, Vol. 71, No. 1, 01.01.2000, p. 36-43.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Comparison of total body chlorine, potassium, and water measurements in children with cystic fibrosis

AU - Borovnicar, Daniel J.

AU - Stroud, Daniel B.

AU - Bines, Julie E.

AU - Haslam, Ric H.M.

AU - Strauss, Boyd J.G.

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N2 - Background: Symptoms of cystic fibrosis (CF) may limit the utility of total body chlorine (TBCl) and total body potassium (TBK) measurements for assessing body fluid compartments of children. Objective: This study assessed relations among independent measurements of TBCl. TBK, and total body water (TBW) in children with CF. Design: We compared cross-sectional measurements of TBCl by in vivo neutron activation analysis, TBK by whole-body counting of 40K. TBW by D2O dilution [TBW(D2O)], and TBW from TBCl and TBK [TBW(Cl + K)] in 19 prepubertal children (13 boys) aged 7.6-12.5 y who had mild symptoms of CF. Body-composition measurements were compared with data from previous studies of healthy children. Results: Subjects with CF had deficits in TBCl, TBK, TBW, and body weight compared with control reference data (P < 0.05). The ratios (TBCl + TBK)/TBW and TBCl/TBK were not significantly different from control reference values, and plasma chlorine and potassium concentrations were within control reference ranges. The sum of TBCl and TBK correlated with TBW(D2O) (r2 = 0.79, P < 0.001), and TBW(Cl + K) correlated with TBW(D2O) (r2 = 0.78, P < 0.001). TBW(Cl + K) was similar to TBW(D2O) (x̄ ± SEM: 19.0 ± 0.5 compared with 19.4 ± 0.5 L; NS). Conclusions: Prepubertal children with mild symptoms of CF can develop deficits in TBCl. TBK, and TBW that reflect chronic energy malnutrition. Mild symptoms of CF do not appear to affect normal relations among TBCl, TBK, and TBW. Measurements of TBCl and TBK may be used to assess body fluid compartments in these patients.

AB - Background: Symptoms of cystic fibrosis (CF) may limit the utility of total body chlorine (TBCl) and total body potassium (TBK) measurements for assessing body fluid compartments of children. Objective: This study assessed relations among independent measurements of TBCl. TBK, and total body water (TBW) in children with CF. Design: We compared cross-sectional measurements of TBCl by in vivo neutron activation analysis, TBK by whole-body counting of 40K. TBW by D2O dilution [TBW(D2O)], and TBW from TBCl and TBK [TBW(Cl + K)] in 19 prepubertal children (13 boys) aged 7.6-12.5 y who had mild symptoms of CF. Body-composition measurements were compared with data from previous studies of healthy children. Results: Subjects with CF had deficits in TBCl, TBK, TBW, and body weight compared with control reference data (P < 0.05). The ratios (TBCl + TBK)/TBW and TBCl/TBK were not significantly different from control reference values, and plasma chlorine and potassium concentrations were within control reference ranges. The sum of TBCl and TBK correlated with TBW(D2O) (r2 = 0.79, P < 0.001), and TBW(Cl + K) correlated with TBW(D2O) (r2 = 0.78, P < 0.001). TBW(Cl + K) was similar to TBW(D2O) (x̄ ± SEM: 19.0 ± 0.5 compared with 19.4 ± 0.5 L; NS). Conclusions: Prepubertal children with mild symptoms of CF can develop deficits in TBCl. TBK, and TBW that reflect chronic energy malnutrition. Mild symptoms of CF do not appear to affect normal relations among TBCl, TBK, and TBW. Measurements of TBCl and TBK may be used to assess body fluid compartments in these patients.

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KW - Extracellular water

KW - Intracellular water

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KW - Total body water

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