Comparison of the performance of different silicon-based SALDI substrates for illicit drug detection

T. Guinan, M. Ronci, R. Vasani, H. Kobus, Nicolas Voelcker

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)


Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) is an emerging technique used for the detection of small molecules (<700 Da) such as illicit drugs. In recent times, this technique has been employed for the detection of illicit drugs in various body fluids including saliva. Three common SALDI techniques, desorption ionization on porous silicon (DIOS), nanostructure-initiator mass spectrometry (NIMS) and nanostructured laser desorption ionization (NALDI) are compared for the detection of four drug classes, amphetamines, benzodiazepines, opiates and tropane alkaloids. We focus in our comparison on structural and chemical characteristics, as well as analytical performance and longevity.

Original languageEnglish
Pages (from-to)494-502
Number of pages9
Publication statusPublished - 15 Jan 2015
Externally publishedYes


  • DIOS
  • Drug detection
  • NIMS

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