The present study was undertaken in an effort to better understand the notched fatigue life behavior of Ti-10V-2Fe-3Al alloy and its origins. In this work, the effects of metallurgical variables (viz., alpha phase aspect ratio and strength level) have been determined on the resistance to both fatigue crack initiation and propagation. From these data, computations were made to synthesize notched fatigue life for the different microstructural conditions. For this purpose, crack propagation life was integrated for the same specimen geometry and loading conditions for which a notched fatigue life question was raised in prior work. Similar computations were made for a variety of T1-6A1-4V microstructural conditions for which counterpart data were available. Of prime significance, the results indicate that notched fatigue life of Ti-10V-2Fe-3Al at the 190 ksi (1310 MPa) strength level is substantially superior to that of Ti-6Al-4V for the respective conditions examined. Moreover, it was found that a reduction in strength level of Ti-10V-2Fe-3Al to 150 ksi (1034 MPa) ultimate tensile strength can degrade notched fatigue life to levels associated with the Ti-6Al-4V microstructures.