Comparison of the effects of nebulized terbutaline with intravenous enprofylline in patients with acute asthma.

R. Ruffin, D. Bryant, J. Burdon, G. Marlin, C. Mitchell, R. O'Hehir, J. Wilson, A. Woolcock, S. Webb

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We compared the bronchodilating effects of intravenously administered enprofylline (2 mg/kg) with nebulized terbutaline (10 mg) in patients presenting to hospital with acute asthma in a multicenter double-blind parallel study. One hundred twenty three patients were randomized into the study, and 69 of these fulfilled the inclusion criteria and a retrospective time to study entry criterion; 34 received enprofylline and 35 received terbutaline. There was no significant difference in maximum increase in forced expired volume in 1 second (FEV1) between the enprofylline group (0.24 +/- 0.33 L) and the terbutaline group (0.25 +/- 0.28 L) (p greater than 0.05), nor for the increase in FEV1 over the 1-hour study period. Tremor was reported more in the group receiving terbutaline, and nausea was reported more in the group receiving enprofylline. Two patients experienced hypotension and one patient had a vasovagal episode with enprofylline treatment. Both agents acted as bronchodilators with similar efficacy in patients with acute asthma in this study.

Original languageEnglish
Pages (from-to)510-514
Number of pages5
Issue number3
Publication statusPublished - 1 Jan 1988
Externally publishedYes

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