Comparison of participants and nonparticipants in a neuroendocrine investigation of psychosis

N. A. Keks, D. L. Copolov, B. Mackie, G. W. Stuart, B. S. Singh, P. D. McGorry, C. Coffey

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Of all neuroleptic‐naive, acutely psychotic subjects admitted to hospital over a 2‐year period (n= 62), 27 participated in a neuroendocrine study and 35 did not participate (51% refused consent, 19% were incapable of consent and 31% started neuroleptics immediately). However, all nonparticipants agreed to psychopathological evaluation, thus allowing comparison between participants and nonparticipants. The 2 groups were similar in most respects, except that more nonparticipants were hostile. Among subjects with schizophrenia, 47% of nonparticipants had the paranoid subtype vs 8% of participants. There was also a trend towards longer illness duration in nonparticipants. These results underline the need for neurobiological studies of psychosis to consider sample bias as a confounding variable.

Original languageEnglish
Pages (from-to)373-376
Number of pages4
JournalActa Psychiatrica Scandinavica
Issue number5
Publication statusPublished - 1 Jan 1991
Externally publishedYes


  • bias
  • consent
  • psychosis
  • sampling
  • schizophrenia

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