Comparative susceptibility of Aedes albopictus and Aedes aegypti to dengue virus infection after feeding on blood of viremic humans: Implications for public health

James Whitehorn, Duong Thi Hue Kien, Nguyet Minh Nguyen, Hoa L Nguyen, Peter P. Kyrylos, Lauren B. Carrington, Chau Nguyen Bich Tran, Nguyen Thanh Ha Quyen, Long Vo Thi, Dui Le Thi, Nguyen Thanh Truong, Thi Hue Tai Luong, Chau Van Vinh Nguyen, Bridget Wills, Marcel Wolbers, Cameron P. Simmons

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Abstract

Aedes albopictus is secondary to Aedes aegypti as a vector of dengue viruses (DENVs) in settings of endemicity, but it plays an important role in areas of dengue emergence. This study compared the susceptibility of these 2 species to DENV infection by performing 232 direct blood-feeding experiments on 118 viremic patients with dengue in Vietnam. Field-derived A. albopictus acquired DENV infections as readily as A. aegypti after blood feeding. Once infected, A. albopictus permitted higher concentrations of DENV RNA to accumulate in abdominal tissues, compared with A. aegypti. However, the odds of A. albopictus having infectious saliva were lower than the odds observed for A. aegypti (odds ratio, 0.70; 95% confidence interval,. 52-.93). These results quantitate the susceptibility of A. albopictus to DENV infection and will assist parameterization of models for predicting disease risk in settings where A. albopictus is present.

Original languageEnglish
Pages (from-to)1182-1190
Number of pages9
JournalJournal of Infectious Diseases
Volume212
Issue number8
DOIs
Publication statusPublished - 15 Oct 2015
Externally publishedYes

Keywords

  • Aedes aegypti
  • Aedes albopictus
  • Dengue
  • susceptibility
  • transmission

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