Abstract
The 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid (Barany) linker and its monomethoxy analog were applied to the Multipin™ method of solid phase synthesis. A comparative assessment of reductive amination and cleavage of these linkers under conditions of multiple synthesis indicated that both were applicable to a broad range of primary amines including aniline and 4-nitroaniline. Apart from the greater lability of the dimethoxy version under TFA cleavage, there was no observable advantage of one linker over the other within the described experiment.
Original language | English |
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Pages (from-to) | 155-163 |
Number of pages | 9 |
Journal | Molecular Diversity |
Volume | 4 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 1998 |
Externally published | Yes |
Keywords
- Linkers
- N-alkylamides
- Reductive amination
- Solid-phase synthesis