TY - JOUR
T1 - Comparative psychometric performance of common generic paediatric health-related quality of life instrument descriptive systems
T2 - results from the Australian Paediatric Multi-Instrument Comparison Study
AU - Jones, Renee
AU - O’Loughlin, Rachel
AU - Xiong, Xiuqin
AU - Bahrampour, Mina
AU - Devlin, Nancy
AU - Hiscock, Harriet
AU - Chen, Gang
AU - Mulhern, Brendan
AU - Dalziel, Kim
AU - on behalf of the Quality of Life in Kids: Key Evidence for Decision Makers in Australia (QUOKKA) Project Team
N1 - Funding Information:
Open Access funding enabled and organized by CAUL and its Member Institutions. This research was funded by an Australian Government Medical Research Futures Fund (MRFF) grant (1200816) and a EuroQol Research Foundation Grant (361-RA). RJ and RO are supported by a Research Training Program Scholarship provided by the Australian Commonwealth Government and the University of Melbourne. RJ is also supported by a EuroQol Research Foundation PhD Grant (330-PhD). HH is funded by a National Health and Medical Research Council (NHMRC) Practitioner Fellowship (1136222). The Murdoch Children’s Research Institute is supported by the Victorian Government’s Operational Infrastructure Support Program.
Funding Information:
This article is published in a journal supplement wholly funded by the Australian Government MRFF funded QUOKKA research grant 1200816, the University of Melbourne, the EuroQol Research Foundation, the University of Technology Sydney and Flinders University.
Funding Information:
KD, ND, BM, HH, and RJ have all received previous or current funding from the EuroQol Research Foundation, who is the developer and copyright holder of some instruments included in this study. ND and BM are members of the EuroQol Group. The EuroQol Research Foundation contributed to funding for this research. Views expressed in this paper are those of the authors and are not necessarily those of the EuroQol Research Foundation.
Publisher Copyright:
© 2023, The Author(s).
PY - 2024
Y1 - 2024
N2 - Objective: The aim of this study was to compare the psychometric performance of common generic paediatric health-related quality-of-life instrument descriptive systems (PedsQL generic core 4.0, EQ-5D-Y-3L, EQ-5D-Y-5L, Child Health Utility 9D [CHU9D], Assessment of Quality of Life 6D [AQoL-6D], and Health Utilities Index Mark 3 [HUI3]) by child age, report type, and health status. Methods: Data for children aged 5–18 years were from the Australian Paediatric Multi-Instrument Comparison study. Ceiling effects, test–retest reliability, known-group validity, convergent and divergent validity, and responsiveness were assessed in the total sample and by child age (5–12 years vs 13–18 years), report type (self- vs proxy report), and health status. Instruments were scored using an exploratory level sum score (LSS) approach. Results: Survey data were available for 5945 children, with follow-up data available for 2346 children. The EQ-5D-Y-3L demonstrated ceiling effects. The PedsQL, EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU9D demonstrated acceptable test–retest reliability. All instruments demonstrated known-group, convergent, and divergent validity. The EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU9D demonstrated responsiveness to improvements in health and the PedsQL, EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU9D to worsening health. The AQoL-6D and HUI3 had inconclusive test–retest reliability and responsiveness evidence due to small sample size. Importantly, ceiling effects, test–retest reliability and responsiveness varied by subgroup. Conclusion: Results reflect instrument performance using LSSs, which may differ to utility scores. In the total sample, the EQ-5D-Y-5L and CHU9D descriptive systems demonstrated evidence of good performance (i.e., meeting prespecified criteria) across all psychometric attributes tested. Performance varied by child age and report type, indicating room for considerations by population and study.
AB - Objective: The aim of this study was to compare the psychometric performance of common generic paediatric health-related quality-of-life instrument descriptive systems (PedsQL generic core 4.0, EQ-5D-Y-3L, EQ-5D-Y-5L, Child Health Utility 9D [CHU9D], Assessment of Quality of Life 6D [AQoL-6D], and Health Utilities Index Mark 3 [HUI3]) by child age, report type, and health status. Methods: Data for children aged 5–18 years were from the Australian Paediatric Multi-Instrument Comparison study. Ceiling effects, test–retest reliability, known-group validity, convergent and divergent validity, and responsiveness were assessed in the total sample and by child age (5–12 years vs 13–18 years), report type (self- vs proxy report), and health status. Instruments were scored using an exploratory level sum score (LSS) approach. Results: Survey data were available for 5945 children, with follow-up data available for 2346 children. The EQ-5D-Y-3L demonstrated ceiling effects. The PedsQL, EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU9D demonstrated acceptable test–retest reliability. All instruments demonstrated known-group, convergent, and divergent validity. The EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU9D demonstrated responsiveness to improvements in health and the PedsQL, EQ-5D-Y-3L, EQ-5D-Y-5L, and CHU9D to worsening health. The AQoL-6D and HUI3 had inconclusive test–retest reliability and responsiveness evidence due to small sample size. Importantly, ceiling effects, test–retest reliability and responsiveness varied by subgroup. Conclusion: Results reflect instrument performance using LSSs, which may differ to utility scores. In the total sample, the EQ-5D-Y-5L and CHU9D descriptive systems demonstrated evidence of good performance (i.e., meeting prespecified criteria) across all psychometric attributes tested. Performance varied by child age and report type, indicating room for considerations by population and study.
UR - http://www.scopus.com/inward/record.url?scp=85176389219&partnerID=8YFLogxK
U2 - 10.1007/s40273-023-01330-2
DO - 10.1007/s40273-023-01330-2
M3 - Article
C2 - 37955799
AN - SCOPUS:85176389219
SN - 1170-7690
VL - 42
SP - 39
EP - 55
JO - PharmacoEconomics
JF - PharmacoEconomics
ER -
