Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep

Kashyap Patel, MT Rademaker, Carl Michael James Kirkpatrick, Christopher J Charles, S Fisher, Tim Yandle, A Mark Richards

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE The urocortin (Ucn) peptides are emerging as potential therapeutic targets for heart disease. However, pharmacokinetic (PK) and pharmacodynamic (PD) data are lacking. Therefore, we investigated the PK/PD for all three Ucns.
Original languageEnglish
Pages (from-to)1916 - 1925
Number of pages10
JournalBritish Journal of Pharmacology
Volume166
DOIs
Publication statusPublished - 2012

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