BACKGROUND AND PURPOSE The urocortin (Ucn) peptides are emerging as potential therapeutic targets for heart disease. However, pharmacokinetic (PK) and pharmacodynamic (PD) data are lacking. Therefore, we investigated the PK/PD for all three Ucns.
Patel, K., Rademaker, MT., Kirkpatrick, C. M. J., Charles, C. J., Fisher, S., Yandle, T., & Richards, A. M. (2012). Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. British Journal of Pharmacology, 166, 1916 - 1925. https://doi.org/10.1111/j.1476-5381.2012.01904.x