Comparative performance and mapping algorithms between EQ-5D-5L and SF-6Dv2 among the Chinese general population

Shitong Xie, Jing Wu, Gang Chen

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Objectives: To explore the comparative performance and develop the mapping algorithms between EQ-5D-5L and SF-6Dv2 in China. Methods: Respondents recruited from the Chinese general population completed both EQ-5D-5L and SF-6Dv2 during face-to-face interviews. Ceiling/floor effects were reported. Discriminative validity in self-reported chronic conditions was investigated using the effect sizes (ES). Test–retest reliability was evaluated using intra-class correlation coefficient (ICC) and Bland–Altman plots in a subsample. Correlation and absolute agreements between the two measures were estimated with Spearman’s rank correlation coefficient and ICC, respectively. Ordinary least squares (OLS), generalized linear model, Tobit model, and robust MM-estimator were explored to estimate mapping equations between EQ-5D-5L and SF-6Dv2. Results: 3320 respondents (50.3% males; age 18–90 years) were recruited. 51.1% and 12.2% of respondents reported no problems on all EQ-5D-5L and SF-6Dv2 dimensions, respectively. The mean EQ-5D-5L utility was higher than SF-6Dv2 (0.947 vs. 0.827, p < 0.001). Utilities were significantly different across all chronic conditions groups for both measures. The mean absolute difference of utilities between the two tests for EQ-5D-5L was smaller (0.033 vs. 0.043) than SF-6Dv2, with a slightly higher ICC (0.859 vs. 0.827). Fair agreement (ICC = 0.582) was observed in the utilities between the two measures. Mapping algorithms generated by the OLS models performed the best according to the goodness-of-fit indicators. Conclusions: Both measures showed comparable discriminative validity. Systematic differences in utilities were found, and on average, the EQ-5D-5L generates higher values than the SF-6Dv2. Mapping algorithms between the EQ-5D-5L and SF-6Dv2 are reported to enable transformations between these two measures in China.

Original languageEnglish
Pages (from-to)7-19
Number of pages13
JournalThe European Journal of Health Economics
Volume25
DOIs
Publication statusPublished - 2024

Keywords

  • China
  • Discriminative validity
  • EQ-5D
  • Mapping
  • SF-6D
  • Test–retest reliability

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