Comparative genomic analysis of Mycobacterium iranicum UM-TJL against representative mycobacterial species suggests its environmental origin

Joon Liang Tan, Yun Fong Ngeow, Wei Yee Wee, Guat Jah Wong, Hien Fuh Ng, Siew Woh Choo

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Mycobacterium iranicum is a newly reported mycobacterial species. We present the first comparative study of M. iranicum UM-TJL and other mycobacteria. We found M. iranicum to have a close genetic association with environmental mycobacteria infrequently associated with human infections. Nonetheless, UM-TJL is also equipped with many virulence genes (some of which appear to be the consequence of transduction-related gene transfer) that have been identified in established human pathogens. Taken all together, our data suggest that M. iranicum is an environmental bacterium adapted for pathogenicity in the human host. This comparative study provides important clues and forms the basis for future functional studies on this mycobacterium.

Original languageEnglish
Article number7169
JournalScientific Reports
Publication statusPublished - 24 Nov 2014
Externally publishedYes

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