Comparative epidemiology of suspected perioperative hypersensitivity reactions

P. M. Mertes, Didier Ebo, Tomaz Garcez, Michael Rose, Vito Sabato, Tomonori Takazawa, Peter Cooke, Russell Clarke, Pascale Dewachter, Lene Garvey, Anne Berit Guttormsen, David L. Hepner, Philip Hopkins, David Khan, Helen Kolawole, Peter Kopac, Mogens Kroigaard, Jose Julio Laguna, Stuart Marshall, Peter PlattPaul Sadleir, Louise Savic, Sinisa Savic, Gerald Volcheck, Susanna Voltolini

Research output: Contribution to journalReview ArticleResearchpeer-review

80 Citations (Scopus)


Suspected perioperative hypersensitivity reactions are rare but contribute significantly to the morbidity and mortality of surgical procedures. Recent publications have highlighted the differences between countries concerning the respective risk of different drugs, and changes in patterns of causal agents and the emergence of new allergens. This review summarises recent information on the epidemiology of perioperative hypersensitivity reactions, with specific consideration of differences between geographic areas for the most frequently involved offending agents.

Original languageEnglish
Pages (from-to)e16-e28
JournalBritish Journal of Anaesthesia
Issue number1
Publication statusPublished - Jul 2019


  • antibiotics
  • blood products
  • chlorhexidine
  • latex
  • neuromuscular blocking agents
  • perioperative anaphylaxis
  • perioperative hypersensitivity
  • sugammadex

Cite this