Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Yuxiang Dong; Darren John Creek; Jacques Chollet; Hugues Matile; Susan Ann Charman; Sergio Wittlin; James H Woods; Jonathan Vennerstrom

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Yuxiang Dong, Darren John Creek, Jacques Chollet, Hugues Matile, Susan Ann Charman, Sergio Wittlin, James H Woods, Jonathan Vennerstrom

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Six tetraozanes had 50 inhibitory concentrations in the range of 10 to 100 ng/ml against plasmodium falciparum, whreas the corresponding hexaoxonanes had minimal antimalrial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activiation

Original language	English
Pages (from-to)	3033 - 3035
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	8
Publication status	Published - 2007

Cite this

@article{831a15ea10634888b40fb9be2d08bc72,

title = "Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)",

abstract = "Six tetraozanes had 50 inhibitory concentrations in the range of 10 to 100 ng/ml against plasmodium falciparum, whreas the corresponding hexaoxonanes had minimal antimalrial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activiation",

author = "Yuxiang Dong and Creek, {Darren John} and Jacques Chollet and Hugues Matile and Charman, {Susan Ann} and Sergio Wittlin and Woods, {James H} and Jonathan Vennerstrom",

year = "2007",

language = "English",

volume = "51",

pages = "3033 -- 3035",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "8",

}

TY - JOUR

T1 - Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

AU - Dong, Yuxiang

AU - Creek, Darren John

AU - Chollet, Jacques

AU - Matile, Hugues

AU - Charman, Susan Ann

AU - Wittlin, Sergio

AU - Woods, James H

AU - Vennerstrom, Jonathan

PY - 2007

Y1 - 2007

N2 - Six tetraozanes had 50 inhibitory concentrations in the range of 10 to 100 ng/ml against plasmodium falciparum, whreas the corresponding hexaoxonanes had minimal antimalrial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activiation

AB - Six tetraozanes had 50 inhibitory concentrations in the range of 10 to 100 ng/ml against plasmodium falciparum, whreas the corresponding hexaoxonanes had minimal antimalrial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activiation

M3 - Article

SN - 0066-4804

VL - 51

SP - 3033

EP - 3035

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -