Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Yuxiang Dong, Darren John Creek, Jacques Chollet, Hugues Matile, Susan Ann Charman, Sergio Wittlin, James H Woods, Jonathan Vennerstrom

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Six tetraozanes had 50 inhibitory concentrations in the range of 10 to 100 ng/ml against plasmodium falciparum, whreas the corresponding hexaoxonanes had minimal antimalrial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activiation
Original languageEnglish
Pages (from-to)3033 - 3035
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number8
Publication statusPublished - 2007

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