Abstract
Substantial evidence supports dysregulated B-cell immune responses in patients with primary biliary cirrhosis (PBC), including the presence of serum antimitochondrial antibodies (AMAs). However, recent reports from murine models of PBC suggest that B cells may also provide regulatory function, and indeed the absence of B cells in such models leads to exacerbation of disease. The vast majority of patients with PBC have readily detectable AMAs, but a minority (
Original language | English |
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Pages (from-to) | 1495 - 1506 |
Number of pages | 12 |
Journal | Hepatology |
Volume | 55 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2012 |