Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis

Qinglong Jin, Yuki Moritoki, Ana Lleo, Koichi Tsuneyama, Pietro Invernizzi, Hitoshi Moritoki, Kentaro Kikuchi, Zhe-Xiong Lian, Gideon M Hirschfield, Aftab A Ansari, Ross L Coppel, M Eric Gershwin, Junqi Niu

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27 Citations (Scopus)

Abstract

Substantial evidence supports dysregulated B-cell immune responses in patients with primary biliary cirrhosis (PBC), including the presence of serum antimitochondrial antibodies (AMAs). However, recent reports from murine models of PBC suggest that B cells may also provide regulatory function, and indeed the absence of B cells in such models leads to exacerbation of disease. The vast majority of patients with PBC have readily detectable AMAs, but a minority (
Original languageEnglish
Pages (from-to)1495 - 1506
Number of pages12
JournalHepatology
Volume55
Issue number5
DOIs
Publication statusPublished - 2012

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