Comparative analysis of calendar time-specific and conventional propensity score analysis for thiazolidinedione use in diabetes

Piyameth Dilokthornsakul, Nathorn Chaiyakunapruk, Napawan Jeanpeerapong, Todd A Lee

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Objectives To evaluate whether there are differences in propensity score (PS) and treatment effects estimated using conventional and calendar time-specific PS (CTS-PS) approaches. Methods A retrospective database analysis at a university-affiliated hospital in Thailand was used. Diabetic patients receiving glucose-lowering medications from July 2008 to June 2011 were included. Patients were categorized into those exposed and not exposed to thiazolidinediones (TZDs). PSs were estimated by using conventional PS and CTS-PS. In the CTS-PS, PS was separately estimated for three specific calendar time periods. Patients were matched 1:1 using caliper matching. The outcomes were cardiovascular and all-cause hospitalizations. The TZD and non-TZD groups were compared with Cox proportional hazard models.
    Original languageEnglish
    Pages (from-to)222 - 228
    Number of pages7
    JournalValue in Health Regional Issues
    Volume3
    DOIs
    Publication statusPublished - 2014

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