TY - JOUR
T1 - Comparable population pharmacokinetics and pharmacodynamic breakpoints of cefpirome in cystic fibrosis patients and healthy volunteers
AU - Bulitta, Jurgen
AU - Kinzig, Martina
AU - Landersdorfer, Cornelia
AU - Holzgrabe, Ulrike
AU - Stephan, U
AU - Sorgel, Fritz
PY - 2011
Y1 - 2011
N2 - Cystic fibrosis (CF) patients are often reported to have higher clearances and larger volumes of distribution per kilogram of total body weight (WT) for beta-lactams than healthy volunteers. As pharmacokinetic (PK) data on cefpirome from studies of CF patients are lacking, we systematically compared its population PK and pharmacodynamic breakpoints for CF patients and healthy volunteers of similar body size.
AB - Cystic fibrosis (CF) patients are often reported to have higher clearances and larger volumes of distribution per kilogram of total body weight (WT) for beta-lactams than healthy volunteers. As pharmacokinetic (PK) data on cefpirome from studies of CF patients are lacking, we systematically compared its population PK and pharmacodynamic breakpoints for CF patients and healthy volunteers of similar body size.
UR - http://aac.asm.org/content/55/6/2927
U2 - 10.1128/AAC.01484-10
DO - 10.1128/AAC.01484-10
M3 - Article
SN - 0066-4804
VL - 55
SP - 2927
EP - 2936
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 6
ER -