Comparable population pharmacokinetics and pharmacodynamic breakpoints of cefpirome in cystic fibrosis patients and healthy volunteers

Jurgen Bulitta, Martina Kinzig, Cornelia Landersdorfer, Ulrike Holzgrabe, U Stephan, Fritz Sorgel

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Cystic fibrosis (CF) patients are often reported to have higher clearances and larger volumes of distribution per kilogram of total body weight (WT) for beta-lactams than healthy volunteers. As pharmacokinetic (PK) data on cefpirome from studies of CF patients are lacking, we systematically compared its population PK and pharmacodynamic breakpoints for CF patients and healthy volunteers of similar body size.
Original languageEnglish
Pages (from-to)2927 - 2936
Number of pages10
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number6
DOIs
Publication statusPublished - 2011
Externally publishedYes

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