Common variants at 12q15 and 12q24 are associated with infant head circumference

H. Rob Taal; Beate St Pourcain; Elisabeth Thiering; Shikta Das; Dennis O. Mook-Kanamori; Nicole M Warrington; Marika Kaakinen; Eskil Kreiner-Møller; Jonathan P. Bradfield; Rachel M. Freathy; Frank Geller; Mònica Guxens; Diana L. Cousminer; Marjan Kerkhof; Nicholas J. Timpson; M. Arfan Ikram; Lawrence J. Beilin; Klaus Bønnelykke; Jessica L. Buxton; Pimphen Charoen; Bo Lund Krogsgaard Chawes; Johan Gunnar Eriksson; David M. Evans; Albert Hofman; John P Kemp; Cecilia E. Kim; Norman Klopp; Jari Marko Lahti; Stephen J. Lye; George McMahon; Frank D. Mentch; Martina Müller-Nurasyid; Paul F. O'Reilly; Inga Prokopenko; Fernando Rivadeneira; Eric A.P. Steegers; Jordi Sunyer; Carla M T Tiesler; Hanieh Yaghootkar; Myriam Fornage; Albert Vernon Smith; Sudha Seshadri; Reinhold Schmidt; Stéphanie Debette; Henri A. Vrooman; Sigurdur Sigurdsson; Stefan Ropele; Laura H Coker; William T Longstreth Jr; Wiro J Niessen; Anita L DeStefano; Alexa Beiser; Alex P Zijdenbos; Maksim Struchalin; Clifford R Jack Jr; Mike A Nalls; Rhoda Au; Haukur Gudnason; Aad van der Lugt; Tamara B Harris; William M. Meeks; Meike W Vernooij; Mark A van Buchem; Diane Catellier; Vilmundur G Gudnason; Beverly Gwen Windham; Philip A Wolf; Cornelia M van Duijn; Thomas H Mosley; Helena Schmidt; Lenore J Launer; Monique M B Breteler; Wei Ang; Toos Van Beijsterveldt; Nienke Bergen; Kelly Benke; Diane Berry; Lachlan Coin; Paul Elliott; Tim Frayling; Romy Gaillard; Maria Groen-Blokhuis; Dexter Hadley; Jouke Jan Hottenga; Ville Huikari; Elina Hypponen; Matthew Kowgier; Debbie A. Lawlor; Alex Lewin; Cecilia Lindgren; Julie A. Marsh; Christel Middeldorp; Iona Y Millwood; Michel Nivard; Lyle J Palmer; Alina Rodriguez; Sylvain Sebert; Ulla Sovio; Marie Standl; David P Strachan; H. Rob Taal; Andre G Uitterlinden; Beatriz Valcárcel; Scott W. White; Gonneke Willemsen; Dorret I Boomsma; Xavier Estivill; Struan F A Grant; Andrew T. Hattersley; Joachim Heinrich; Vincent W V Jaddoe; Marjo-Riitta Jarvelin; Mark I. McCarthy; Craig E. Pennell; Chris Power; Elisabeth Widen; Alexandra I.F. Blakemore; Rosetta M. Chiavacci; Bjarke Feenstra; Julio Fernandez-Banet; Anna-Liisa Hartikainen; Albert J. Van Der Heijden; Carmen Iñiguez; Mark G Lathrop; Wendy L McArdle; Anne Mølgaard; John P. Newnham; Aarno Palotie; Annneli Pouta; Susan M Ring; H. Erich Wichmann; Nadja Hawwa Vissing; Charles S DeCarli; Gerard H Koppelman; Mads Melbye; Hans Bisgaard; Hakon Hakonarson; George Davey Smith; Vincent W V Jaddoe; Linda S. Adair; Mustafa Atalay; Oliver S.P. Davis; Claudia Flexeder; Liang Kee Goh; Claire M.A. Haworth; Johannes Hedebrand; Anke Hinney; Joel N Hirschhorn; John W. Holloway; Claus Holst; Momoko Horikoshi; Tuomas O. Kilpeläinen; Mirna Kirin; Hanna Maaria Lakka; Leslie A. Lange; Terho Lehtimäki; Virpi Lindi; Reedik Maggi; Jeffrey Clark Murray; Ellen Aagaard Nohr; Ioanna Ntalla; Emily Oken; Kalliope Panoutsopoulou; Jennifer Pararajasingham; Rany M. Salem; Niina Siitonen; H. Rob Taal; Yik Ying Teo; Eleftheria Zeggini; Cyrus Cooper; Matthew Gillman; Berthold Hocher; Timo A. Lakka; Karen L. Mohlke; George V. Dedoussis; Ken K. Ong; Ewan R. Pearson; Thomas S. Price; Olli T Raitakari; Seang Mei Saw; Andre Scherag; Olli Simell; Thorkild I A Sørensen; James F Wilson

doi:10.1038/ng.2238

Common variants at 12q15 and 12q24 are associated with infant head circumference

H. Rob Taal, Beate St Pourcain, Elisabeth Thiering, Shikta Das, Dennis O. Mook-Kanamori, Nicole M Warrington, Marika Kaakinen, Eskil Kreiner-Møller, Jonathan P. Bradfield, Rachel M. Freathy, Frank Geller, Mònica Guxens, Diana L. Cousminer, Marjan Kerkhof, Nicholas J. Timpson, M. Arfan Ikram, Lawrence J. Beilin, Klaus Bønnelykke, Jessica L. Buxton, Pimphen CharoenBo Lund Krogsgaard Chawes, Johan Gunnar Eriksson, David M. Evans, Albert Hofman, John P Kemp, Cecilia E. Kim, Norman Klopp, Jari Marko Lahti, Stephen J. Lye, George McMahon, Frank D. Mentch, Martina Müller-Nurasyid, Paul F. O'Reilly, Inga Prokopenko, Fernando Rivadeneira, Eric A.P. Steegers, Jordi Sunyer, Carla M T Tiesler, Hanieh Yaghootkar, Myriam Fornage, Albert Vernon Smith, Sudha Seshadri, Reinhold Schmidt, Stéphanie Debette, Henri A. Vrooman, Sigurdur Sigurdsson, Stefan Ropele, Laura H Coker, William T Longstreth Jr, Wiro J Niessen, Anita L DeStefano, Alexa Beiser, Alex P Zijdenbos, Maksim Struchalin, Clifford R Jack Jr, Mike A Nalls, Rhoda Au, Haukur Gudnason, Aad van der Lugt, Tamara B Harris, William M. Meeks, Meike W Vernooij, Mark A van Buchem, Diane Catellier, Vilmundur G Gudnason, Beverly Gwen Windham, Philip A Wolf, Cornelia M van Duijn, Thomas H Mosley, Helena Schmidt, Lenore J Launer, Monique M B Breteler, Wei Ang, Toos Van Beijsterveldt, Nienke Bergen, Kelly Benke, Diane Berry, Lachlan Coin, Paul Elliott, Tim Frayling, Romy Gaillard, Maria Groen-Blokhuis, Dexter Hadley, Jouke Jan Hottenga, Ville Huikari, Elina Hypponen, Matthew Kowgier, Debbie A. Lawlor, Alex Lewin, Cecilia Lindgren, Julie A. Marsh, Christel Middeldorp, Iona Y Millwood, Michel Nivard, Lyle J Palmer, Alina Rodriguez, Sylvain Sebert, Ulla Sovio, Marie Standl, David P Strachan, H. Rob Taal, Andre G Uitterlinden, Beatriz Valcárcel, Scott W. White, Gonneke Willemsen, Dorret I Boomsma, Xavier Estivill, Struan F A Grant, Andrew T. Hattersley, Joachim Heinrich, Vincent W V Jaddoe, Marjo-Riitta Jarvelin, Mark I. McCarthy, Craig E. Pennell, Chris Power, Elisabeth Widen, Alexandra I.F. Blakemore, Rosetta M. Chiavacci, Bjarke Feenstra, Julio Fernandez-Banet, Anna-Liisa Hartikainen, Albert J. Van Der Heijden, Carmen Iñiguez, Mark G Lathrop, Wendy L McArdle, Anne Mølgaard, John P. Newnham, Aarno Palotie, Annneli Pouta, Susan M Ring, H. Erich Wichmann, Nadja Hawwa Vissing, Charles S DeCarli, Gerard H Koppelman, Mads Melbye, Hans Bisgaard, Hakon Hakonarson, George Davey Smith, Vincent W V Jaddoe, Linda S. Adair, Mustafa Atalay, Oliver S.P. Davis, Claudia Flexeder, Liang Kee Goh, Claire M.A. Haworth, Johannes Hedebrand, Anke Hinney, Joel N Hirschhorn, John W. Holloway, Claus Holst, Momoko Horikoshi, Tuomas O. Kilpeläinen, Mirna Kirin, Hanna Maaria Lakka, Leslie A. Lange, Terho Lehtimäki, Virpi Lindi, Reedik Maggi, Jeffrey Clark Murray, Ellen Aagaard Nohr, Ioanna Ntalla, Emily Oken, Kalliope Panoutsopoulou, Jennifer Pararajasingham, Rany M. Salem, Niina Siitonen, H. Rob Taal, Yik Ying Teo, Eleftheria Zeggini, Cyrus Cooper, Matthew Gillman, Berthold Hocher, Timo A. Lakka, Karen L. Mohlke, George V. Dedoussis, Ken K. Ong, Ewan R. Pearson, Thomas S. Price, Olli T Raitakari, Seang Mei Saw, Andre Scherag, Olli Simell, Thorkild I A Sørensen, James F Wilson

Research output: Contribution to journal › Article › Research › peer-review

94 Citations (Scopus)

Abstract

To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 ^-9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 ^-10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 ^-7 for rs7980687 and P = 1.3 × 10 ^-7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 ^-6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

Original language	English
Pages (from-to)	532-538
Number of pages	7
Journal	Nature Genetics
Volume	44
Issue number	5
DOIs	https://doi.org/10.1038/ng.2238
Publication status	Published - May 2012
Externally published	Yes

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10.1038/ng.2238

Cite this

Rob Taal, H., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D. O., Warrington, N. M., Kaakinen, M., Kreiner-Møller, E., Bradfield, J. P., Freathy, R. M., Geller, F., Guxens, M., Cousminer, D. L., Kerkhof, M., Timpson, N. J., Ikram, M. A., Beilin, L. J., Bønnelykke, K., Buxton, J. L., ... Wilson, J. F. (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44(5), 532-538. https://doi.org/10.1038/ng.2238

@article{65d1211a10234309b84ccb12d611abe4,

title = "Common variants at 12q15 and 12q24 are associated with infant head circumference",

abstract = "To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.",

author = "{Rob Taal}, H. and {St Pourcain}, Beate and Elisabeth Thiering and Shikta Das and Mook-Kanamori, {Dennis O.} and Warrington, {Nicole M} and Marika Kaakinen and Eskil Kreiner-M{\o}ller and Bradfield, {Jonathan P.} and Freathy, {Rachel M.} and Frank Geller and M{\`o}nica Guxens and Cousminer, {Diana L.} and Marjan Kerkhof and Timpson, {Nicholas J.} and Ikram, {M. Arfan} and Beilin, {Lawrence J.} and Klaus B{\o}nnelykke and Buxton, {Jessica L.} and Pimphen Charoen and Chawes, {Bo Lund Krogsgaard} and Eriksson, {Johan Gunnar} and Evans, {David M.} and Albert Hofman and Kemp, {John P} and Kim, {Cecilia E.} and Norman Klopp and Lahti, {Jari Marko} and Lye, {Stephen J.} and George McMahon and Mentch, {Frank D.} and Martina M{\"u}ller-Nurasyid and O'Reilly, {Paul F.} and Inga Prokopenko and Fernando Rivadeneira and Steegers, {Eric A.P.} and Jordi Sunyer and Tiesler, {Carla M T} and Hanieh Yaghootkar and Myriam Fornage and Smith, {Albert Vernon} and Sudha Seshadri and Reinhold Schmidt and St{\'e}phanie Debette and Vrooman, {Henri A.} and Sigurdur Sigurdsson and Stefan Ropele and Coker, {Laura H} and {Longstreth Jr}, {William T} and Niessen, {Wiro J} and DeStefano, {Anita L} and Alexa Beiser and Zijdenbos, {Alex P} and Maksim Struchalin and {Jack Jr}, {Clifford R} and Nalls, {Mike A} and Rhoda Au and Haukur Gudnason and {van der Lugt}, Aad and Harris, {Tamara B} and Meeks, {William M.} and Vernooij, {Meike W} and {van Buchem}, {Mark A} and Diane Catellier and Gudnason, {Vilmundur G} and Windham, {Beverly Gwen} and Wolf, {Philip A} and {van Duijn}, {Cornelia M} and Mosley, {Thomas H} and Helena Schmidt and Launer, {Lenore J} and Breteler, {Monique M B} and Wei Ang and {Van Beijsterveldt}, Toos and Nienke Bergen and Kelly Benke and Diane Berry and Lachlan Coin and Paul Elliott and Tim Frayling and Romy Gaillard and Maria Groen-Blokhuis and Dexter Hadley and Hottenga, {Jouke Jan} and Ville Huikari and Elina Hypponen and Matthew Kowgier and Lawlor, {Debbie A.} and Alex Lewin and Cecilia Lindgren and Marsh, {Julie A.} and Christel Middeldorp and Millwood, {Iona Y} and Michel Nivard and Palmer, {Lyle J} and Alina Rodriguez and Sylvain Sebert and Ulla Sovio and Marie Standl and Strachan, {David P} and {Rob Taal}, H. and Uitterlinden, {Andre G} and Beatriz Valc{\'a}rcel and White, {Scott W.} and Gonneke Willemsen and Boomsma, {Dorret I} and Xavier Estivill and Grant, {Struan F A} and Hattersley, {Andrew T.} and Joachim Heinrich and Jaddoe, {Vincent W V} and Marjo-Riitta Jarvelin and McCarthy, {Mark I.} and Pennell, {Craig E.} and Chris Power and Elisabeth Widen and Blakemore, {Alexandra I.F.} and Chiavacci, {Rosetta M.} and Bjarke Feenstra and Julio Fernandez-Banet and Anna-Liisa Hartikainen and {Van Der Heijden}, {Albert J.} and Carmen I{\~n}iguez and Lathrop, {Mark G} and McArdle, {Wendy L} and Anne M{\o}lgaard and Newnham, {John P.} and Aarno Palotie and Annneli Pouta and Ring, {Susan M} and Wichmann, {H. Erich} and Vissing, {Nadja Hawwa} and DeCarli, {Charles S} and Koppelman, {Gerard H} and Mads Melbye and Hans Bisgaard and Hakon Hakonarson and Smith, {George Davey} and Jaddoe, {Vincent W V} and Adair, {Linda S.} and Mustafa Atalay and Davis, {Oliver S.P.} and Claudia Flexeder and Goh, {Liang Kee} and Haworth, {Claire M.A.} and Johannes Hedebrand and Anke Hinney and Hirschhorn, {Joel N} and Holloway, {John W.} and Claus Holst and Momoko Horikoshi and Kilpel{\"a}inen, {Tuomas O.} and Mirna Kirin and Lakka, {Hanna Maaria} and Lange, {Leslie A.} and Terho Lehtim{\"a}ki and Virpi Lindi and Reedik Maggi and Murray, {Jeffrey Clark} and Nohr, {Ellen Aagaard} and Ioanna Ntalla and Emily Oken and Kalliope Panoutsopoulou and Jennifer Pararajasingham and Salem, {Rany M.} and Niina Siitonen and {Rob Taal}, H. and Teo, {Yik Ying} and Eleftheria Zeggini and Cyrus Cooper and Matthew Gillman and Berthold Hocher and Lakka, {Timo A.} and Mohlke, {Karen L.} and Dedoussis, {George V.} and Ong, {Ken K.} and Pearson, {Ewan R.} and Price, {Thomas S.} and Raitakari, {Olli T} and Saw, {Seang Mei} and Andre Scherag and Olli Simell and S{\o}rensen, {Thorkild I A} and Wilson, {James F}",

year = "2012",

month = may,

doi = "10.1038/ng.2238",

language = "English",

volume = "44",

pages = "532--538",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "5",

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Rob Taal, H, St Pourcain, B, Thiering, E, Das, S, Mook-Kanamori, DO, Warrington, NM, Kaakinen, M, Kreiner-Møller, E, Bradfield, JP, Freathy, RM, Geller, F, Guxens, M, Cousminer, DL, Kerkhof, M, Timpson, NJ, Ikram, MA, Beilin, LJ, Bønnelykke, K, Buxton, JL, Charoen, P, Chawes, BLK, Eriksson, JG, Evans, DM, Hofman, A, Kemp, JP, Kim, CE, Klopp, N, Lahti, JM, Lye, SJ, McMahon, G, Mentch, FD, Müller-Nurasyid, M, O'Reilly, PF, Prokopenko, I, Rivadeneira, F, Steegers, EAP, Sunyer, J, Tiesler, CMT, Yaghootkar, H, Fornage, M, Smith, AV, Seshadri, S, Schmidt, R, Debette, S, Vrooman, HA, Sigurdsson, S, Ropele, S, Coker, LH, Longstreth Jr, WT, Niessen, WJ, DeStefano, AL, Beiser, A, Zijdenbos, AP, Struchalin, M, Jack Jr, CR, Nalls, MA, Au, R, Gudnason, H, van der Lugt, A, Harris, TB, Meeks, WM, Vernooij, MW, van Buchem, MA, Catellier, D, Gudnason, VG, Windham, BG, Wolf, PA, van Duijn, CM, Mosley, TH, Schmidt, H, Launer, LJ, Breteler, MMB, Ang, W, Van Beijsterveldt, T, Bergen, N, Benke, K, Berry, D, Coin, L, Elliott, P, Frayling, T, Gaillard, R, Groen-Blokhuis, M, Hadley, D, Hottenga, JJ, Huikari, V, Hypponen, E, Kowgier, M, Lawlor, DA, Lewin, A, Lindgren, C, Marsh, JA, Middeldorp, C, Millwood, IY, Nivard, M, Palmer, LJ, Rodriguez, A, Sebert, S, Sovio, U, Standl, M, Strachan, DP, Rob Taal, H, Uitterlinden, AG, Valcárcel, B, White, SW, Willemsen, G, Boomsma, DI, Estivill, X, Grant, SFA, Hattersley, AT, Heinrich, J, Jaddoe, VWV, Jarvelin, M-R, McCarthy, MI, Pennell, CE, Power, C, Widen, E, Blakemore, AIF, Chiavacci, RM, Feenstra, B, Fernandez-Banet, J, Hartikainen, A-L, Van Der Heijden, AJ, Iñiguez, C, Lathrop, MG, McArdle, WL, Mølgaard, A, Newnham, JP, Palotie, A, Pouta, A, Ring, SM, Wichmann, HE, Vissing, NH, DeCarli, CS, Koppelman, GH, Melbye, M, Bisgaard, H, Hakonarson, H, Smith, GD, Jaddoe, VWV, Adair, LS, Atalay, M, Davis, OSP, Flexeder, C, Goh, LK, Haworth, CMA, Hedebrand, J, Hinney, A, Hirschhorn, JN, Holloway, JW, Holst, C, Horikoshi, M, Kilpeläinen, TO, Kirin, M, Lakka, HM, Lange, LA, Lehtimäki, T, Lindi, V, Maggi, R, Murray, JC, Nohr, EA, Ntalla, I, Oken, E, Panoutsopoulou, K, Pararajasingham, J, Salem, RM, Siitonen, N, Rob Taal, H, Teo, YY, Zeggini, E, Cooper, C, Gillman, M, Hocher, B, Lakka, TA, Mohlke, KL, Dedoussis, GV, Ong, KK, Pearson, ER, Price, TS, Raitakari, OT, Saw, SM, Scherag, A, Simell, O, Sørensen, TIA & Wilson, JF 2012, 'Common variants at 12q15 and 12q24 are associated with infant head circumference', Nature Genetics, vol. 44, no. 5, pp. 532-538. https://doi.org/10.1038/ng.2238

TY - JOUR

T1 - Common variants at 12q15 and 12q24 are associated with infant head circumference

AU - Rob Taal, H.

AU - St Pourcain, Beate

AU - Thiering, Elisabeth

AU - Das, Shikta

AU - Mook-Kanamori, Dennis O.

AU - Warrington, Nicole M

AU - Kaakinen, Marika

AU - Kreiner-Møller, Eskil

AU - Bradfield, Jonathan P.

AU - Freathy, Rachel M.

AU - Geller, Frank

AU - Guxens, Mònica

AU - Cousminer, Diana L.

AU - Kerkhof, Marjan

AU - Timpson, Nicholas J.

AU - Ikram, M. Arfan

AU - Beilin, Lawrence J.

AU - Bønnelykke, Klaus

AU - Buxton, Jessica L.

AU - Charoen, Pimphen

AU - Chawes, Bo Lund Krogsgaard

AU - Eriksson, Johan Gunnar

AU - Evans, David M.

AU - Hofman, Albert

AU - Kemp, John P

AU - Kim, Cecilia E.

AU - Klopp, Norman

AU - Lahti, Jari Marko

AU - Lye, Stephen J.

AU - McMahon, George

AU - Mentch, Frank D.

AU - Müller-Nurasyid, Martina

AU - O'Reilly, Paul F.

AU - Prokopenko, Inga

AU - Rivadeneira, Fernando

AU - Steegers, Eric A.P.

AU - Sunyer, Jordi

AU - Tiesler, Carla M T

AU - Yaghootkar, Hanieh

AU - Fornage, Myriam

AU - Smith, Albert Vernon

AU - Seshadri, Sudha

AU - Schmidt, Reinhold

AU - Debette, Stéphanie

AU - Vrooman, Henri A.

AU - Sigurdsson, Sigurdur

AU - Ropele, Stefan

AU - Coker, Laura H

AU - Longstreth Jr, William T

AU - Niessen, Wiro J

AU - DeStefano, Anita L

AU - Beiser, Alexa

AU - Zijdenbos, Alex P

AU - Struchalin, Maksim

AU - Jack Jr, Clifford R

AU - Nalls, Mike A

AU - Au, Rhoda

AU - Gudnason, Haukur

AU - van der Lugt, Aad

AU - Harris, Tamara B

AU - Meeks, William M.

AU - Vernooij, Meike W

AU - van Buchem, Mark A

AU - Catellier, Diane

AU - Gudnason, Vilmundur G

AU - Windham, Beverly Gwen

AU - Wolf, Philip A

AU - van Duijn, Cornelia M

AU - Mosley, Thomas H

AU - Schmidt, Helena

AU - Launer, Lenore J

AU - Breteler, Monique M B

AU - Ang, Wei

AU - Van Beijsterveldt, Toos

AU - Bergen, Nienke

AU - Benke, Kelly

AU - Berry, Diane

AU - Coin, Lachlan

AU - Elliott, Paul

AU - Frayling, Tim

AU - Gaillard, Romy

AU - Groen-Blokhuis, Maria

AU - Hadley, Dexter

AU - Hottenga, Jouke Jan

AU - Huikari, Ville

AU - Hypponen, Elina

AU - Kowgier, Matthew

AU - Lawlor, Debbie A.

AU - Lewin, Alex

AU - Lindgren, Cecilia

AU - Marsh, Julie A.

AU - Middeldorp, Christel

AU - Millwood, Iona Y

AU - Nivard, Michel

AU - Palmer, Lyle J

AU - Rodriguez, Alina

AU - Sebert, Sylvain

AU - Sovio, Ulla

AU - Standl, Marie

AU - Strachan, David P

AU - Rob Taal, H.

AU - Uitterlinden, Andre G

AU - Valcárcel, Beatriz

AU - White, Scott W.

AU - Willemsen, Gonneke

AU - Boomsma, Dorret I

AU - Estivill, Xavier

AU - Grant, Struan F A

AU - Hattersley, Andrew T.

AU - Heinrich, Joachim

AU - Jaddoe, Vincent W V

AU - Jarvelin, Marjo-Riitta

AU - McCarthy, Mark I.

AU - Pennell, Craig E.

AU - Power, Chris

AU - Widen, Elisabeth

AU - Blakemore, Alexandra I.F.

AU - Chiavacci, Rosetta M.

AU - Feenstra, Bjarke

AU - Fernandez-Banet, Julio

AU - Hartikainen, Anna-Liisa

AU - Van Der Heijden, Albert J.

AU - Iñiguez, Carmen

AU - Lathrop, Mark G

AU - McArdle, Wendy L

AU - Mølgaard, Anne

AU - Newnham, John P.

AU - Palotie, Aarno

AU - Pouta, Annneli

AU - Ring, Susan M

AU - Wichmann, H. Erich

AU - Vissing, Nadja Hawwa

AU - DeCarli, Charles S

AU - Koppelman, Gerard H

AU - Melbye, Mads

AU - Bisgaard, Hans

AU - Hakonarson, Hakon

AU - Smith, George Davey

AU - Jaddoe, Vincent W V

AU - Adair, Linda S.

AU - Atalay, Mustafa

AU - Davis, Oliver S.P.

AU - Flexeder, Claudia

AU - Goh, Liang Kee

AU - Haworth, Claire M.A.

AU - Hedebrand, Johannes

AU - Hinney, Anke

AU - Hirschhorn, Joel N

AU - Holloway, John W.

AU - Holst, Claus

AU - Horikoshi, Momoko

AU - Kilpeläinen, Tuomas O.

AU - Kirin, Mirna

AU - Lakka, Hanna Maaria

AU - Lange, Leslie A.

AU - Lehtimäki, Terho

AU - Lindi, Virpi

AU - Maggi, Reedik

AU - Murray, Jeffrey Clark

AU - Nohr, Ellen Aagaard

AU - Ntalla, Ioanna

AU - Oken, Emily

AU - Panoutsopoulou, Kalliope

AU - Pararajasingham, Jennifer

AU - Salem, Rany M.

AU - Siitonen, Niina

AU - Rob Taal, H.

AU - Teo, Yik Ying

AU - Zeggini, Eleftheria

AU - Cooper, Cyrus

AU - Gillman, Matthew

AU - Hocher, Berthold

AU - Lakka, Timo A.

AU - Mohlke, Karen L.

AU - Dedoussis, George V.

AU - Ong, Ken K.

AU - Pearson, Ewan R.

AU - Price, Thomas S.

AU - Raitakari, Olli T

AU - Saw, Seang Mei

AU - Scherag, Andre

AU - Simell, Olli

AU - Sørensen, Thorkild I A

AU - Wilson, James F

PY - 2012/5

Y1 - 2012/5

N2 - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

AB - To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 × 10 -9) and rs1042725 on chromosome 12q15 (P = 2.8 × 10 -10) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 × 10 -7 for rs7980687 and P = 1.3 × 10 -7 for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 × 10 -6). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.

UR - http://www.scopus.com/inward/record.url?scp=84860324077&partnerID=8YFLogxK

U2 - 10.1038/ng.2238

DO - 10.1038/ng.2238

M3 - Article

C2 - 22504419

AN - SCOPUS:84860324077

SN - 1061-4036

VL - 44

SP - 532

EP - 538

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Common variants at 12q15 and 12q24 are associated with infant head circumference

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