Common neural substrate for processing depth and direction signals for reaching in the monkey medial posterior parietal cortex

K. Hadjidimitrakis, F. Bertozzi, R. Breveglieri, A. Bosco, C. Galletti, P. Fattori

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Abstract

Many psychophysical studies suggest that target depth and direction during reaches are processed independently, but the neurophysiological support to this view is so far limited. Here, we investigated the representation of reach depth and direction by single neurons in area V6A of the medial posterior parietal cortex (PPC) of macaques, while a fixation-to-reach task in 3-dimensional (3D) space was performed. We found that, in a substantial percentage of V6A neurons, depth and direction signals jointly influenced fixation, planning, and arm movement-related activity. While target depth and direction were equally encoded during fixation, depth tuning became stronger during arm movement planning, execution, and target holding. The spatial tuning of fixation activity was often maintained across epochs, and depth tuning persisted more than directional tuning across epochs. These findings support for the first time the existence of a common neural substrate for the encoding of target depth and direction during reaches in the PPC. Present results also highlight the presence of several types of V6A cells that process independently or jointly signals about eye position and arm movement planning and execution in order to control reaches in 3D space. A conceptual framework for the processing of depth and direction for reaching is proposed.

Original languageEnglish
Pages (from-to)1645-1657
Number of pages13
JournalCerebral Cortex
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Keywords

  • Eye-hand coordination
  • Reach
  • Sensorimotor
  • Vergence
  • Version

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