Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 280 - 285 |
| Number of pages | 6 |
| Journal | Resuscitation |
| Volume | 84 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 |
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Common laboratory tests predict imminent death in ward patients. / Loekito, Elsa; Bailey, James; Bellomo, Rinaldo; Hart, Graeme Keith; Hegarty, Colin; Davey, Peter; Bain, Christopher A; Pilcher, David V; Schneider, Hans.
In: Resuscitation, Vol. 84, No. 3, 2013, p. 280 - 285.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Common laboratory tests predict imminent death in ward patients
AU - Loekito, Elsa
AU - Bailey, James
AU - Bellomo, Rinaldo
AU - Hart, Graeme Keith
AU - Hegarty, Colin
AU - Davey, Peter
AU - Bain, Christopher A
AU - Pilcher, David V
AU - Schneider, Hans
PY - 2013
Y1 - 2013
N2 - Objective: To estimate the ability of commonly measured laboratory variables to predict an imminent (within the same or next calendar day) death in ward patients. Design: Retrospective observational study. Setting: Two university affiliated hospitals. Patients: Cohort of 42,701 patients admitted for more than 24 hours and external validation cohort of 13,137 patients admitted for more than 24 hours. Intervention: We linked commonly measured laboratory tests with event databases and assessed the ability of each laboratory variable or combination of variables together with patient age to predict imminent death. Measurements and main results: In the inception teaching hospital, we studied 418,897 batches of tests in 42,701 patients (males 55 ; average age 65.8 ? 17.6 years), for a total of >2.5 million individual measurements. Among these patients, there were 1596 deaths. Multivariable logistic modelling achieved an AUC-ROC of 0.87 (95 CI: 0.85-0.89) for the prediction of imminent death. Using an additional 105,074 batches from a cohort of 13,137 patients from a second teaching hospital, the multivariate model achieved an AUC-ROC of 0.88 (95 CI: 0.85-0.90). Conclusions: Commonly performed laboratory tests can help predict imminent death in ward patients. Prospective investigations of the clinical utility of such predictions appear justified.
AB - Objective: To estimate the ability of commonly measured laboratory variables to predict an imminent (within the same or next calendar day) death in ward patients. Design: Retrospective observational study. Setting: Two university affiliated hospitals. Patients: Cohort of 42,701 patients admitted for more than 24 hours and external validation cohort of 13,137 patients admitted for more than 24 hours. Intervention: We linked commonly measured laboratory tests with event databases and assessed the ability of each laboratory variable or combination of variables together with patient age to predict imminent death. Measurements and main results: In the inception teaching hospital, we studied 418,897 batches of tests in 42,701 patients (males 55 ; average age 65.8 ? 17.6 years), for a total of >2.5 million individual measurements. Among these patients, there were 1596 deaths. Multivariable logistic modelling achieved an AUC-ROC of 0.87 (95 CI: 0.85-0.89) for the prediction of imminent death. Using an additional 105,074 batches from a cohort of 13,137 patients from a second teaching hospital, the multivariate model achieved an AUC-ROC of 0.88 (95 CI: 0.85-0.90). Conclusions: Commonly performed laboratory tests can help predict imminent death in ward patients. Prospective investigations of the clinical utility of such predictions appear justified.
UR - http://goo.gl/MK7uMn
U2 - 10.1016/j.resuscitation.2012.07.025
DO - 10.1016/j.resuscitation.2012.07.025
M3 - Article
VL - 84
SP - 280
EP - 285
JO - Resuscitation
JF - Resuscitation
SN - 0300-9572
IS - 3
ER -