Common breast cancer susceptibility loci are associated with triple-negative breast cancer

Kristen N. Stevens, Celine M Vachon, Adam M. Lee, Susan Slager, Timothy Lesnick, Curtis Olswold, Peter A. Fasching, Penelope Miron, Diana M Eccles, Jane E. Carpenter, Andrew K. Godwin, Christine B. Ambrosone, Robert Winqvist, Hiltrud Brauch, Marjanka K. Schmidt, Angela Cox, Simon S Cross, Elinor J Sawyer, Arndt Hartmann, Matthias W. BeckmannRud̈iger Schulz-Wendtland, Arif B Ekici, William J Tapper, Susan M. Gerty, Lorraine Durcan, Nikki J. Graham, Rebecca Hein, Stephan Nickels, Dieter Flesch-Janys, Judith Heinz, Hans Peter Sinn, Irene Konstantopoulou, Florentia Fostira, Dimitrios Pectasides, Meletios Athanasios Dimopoulos, George Fountzilas, Christine L Clarke, Rosemary Balleine, Janet E Olson, Zachary Fredericksen, Robert B. Diasio, Harsh Pathak, Eric Ross, Jo Ellen Weaver, Thomas Rüdiger, Asta Försti, Thomas Dünnebier, Foluso Ademuyiwa, Swati Kulkarni, Katri Pylkäs, Arja Jukkola-Vuorinen, Yon-Dschun Ko, Erik Van Limbergen, Hilde Janssen, Julian Peto, Olivia Fletcher, Graham G. Giles, Laura Baglietto, Senno Verhoef, Ian P Tomlinson, Veli-Matti Kosma, Jonathan Beesley, Dario Greco, Carl Blomqvist, Astrid K Irwanto, Jianjun Liu, Fiona M Blows, Sarah-Jane Dawson, Sara Margolin, Arto Mannermaa, Nicholas Gordon Martin, Grant W Montgomery, Diether Lambrechts, Isabel Dos Santos Silva, Gianluca Severi, Ute Hamann, Paul D P Pharoah, Douglas F Easton, Jenny Chang-Claude, Drakoulis Yannoukakos, Heli Nevanlinna, Xianshu Wang, Fergus J Couch

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94 Citations (Scopus)

Abstract

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six singlenucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

Original languageEnglish
Pages (from-to)6240-6249
Number of pages10
JournalCancer Research
Volume71
Issue number19
DOIs
Publication statusPublished - 1 Oct 2011
Externally publishedYes

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