Commensal flora and the regulation of inflammatory and autoimmune responses

Jan Kranich, Kendle M Maslowski, Charles R Mackay

    Research output: Contribution to journalArticleResearchpeer-review

    56 Citations (Scopus)

    Abstract

    The gut microbiota has recently been recognized for its role in immune regulation, and changes in gut microbiota may be the basis for an increased incidence of autoimmune diseases and asthma in developed countries. Beneficial microbes produce factors that are distributed systemically, and therefore can influence peripheral inflammatory responses. Such symbiosis factors are important for the control and resolution of inflammation and autoimmune diseases. Here we discuss immune regulation by recently identified symbiosis factors and how certain environmental factors favor their production and influence the composition of the gut microflora.
    Original languageEnglish
    Pages (from-to)139 - 145
    Number of pages7
    JournalSeminars in Immunology
    Volume23
    Issue number2
    DOIs
    Publication statusPublished - 2011

    Cite this

    Kranich, Jan ; Maslowski, Kendle M ; Mackay, Charles R. / Commensal flora and the regulation of inflammatory and autoimmune responses. In: Seminars in Immunology. 2011 ; Vol. 23, No. 2. pp. 139 - 145.
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    Commensal flora and the regulation of inflammatory and autoimmune responses. / Kranich, Jan; Maslowski, Kendle M; Mackay, Charles R.

    In: Seminars in Immunology, Vol. 23, No. 2, 2011, p. 139 - 145.

    Research output: Contribution to journalArticleResearchpeer-review

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    N2 - The gut microbiota has recently been recognized for its role in immune regulation, and changes in gut microbiota may be the basis for an increased incidence of autoimmune diseases and asthma in developed countries. Beneficial microbes produce factors that are distributed systemically, and therefore can influence peripheral inflammatory responses. Such symbiosis factors are important for the control and resolution of inflammation and autoimmune diseases. Here we discuss immune regulation by recently identified symbiosis factors and how certain environmental factors favor their production and influence the composition of the gut microflora.

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