Combining modelling with advanced experimental techniques to optimize formulation and nozzle design for low GWP pMDIs

Daniel J. Duke; Dung Nguyen; Harry Scott; AJ Kusangaya; Alan L Kastengren; David Schmidt; Damon Honnery

Combining modelling with advanced experimental techniques to optimize formulation and nozzle design for low GWP pMDIs

Daniel J. Duke, Dung Nguyen, Harry Scott, AJ Kusangaya, Alan L Kastengren, David Schmidt, Damon Honnery

Mechanical & Aerospace Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

Abstract

The design of the next generation of pressured metered dose inhalers (pMDIs) will be driven by the transition to low global warming potential (GWP) propellants. One of the major design challenges is the optimization of the actuator nozzle to achieve equivalent or improved outcomes to current generation devices. Thermophysical property changes and a myriad of fluid-mechanical effects complicate the link between formulation and nozzle design. In this paper, using model solution formulations of hydrofluoroalkane 134a (HFA-134a) and HFA-152a propellants, state of the art X-ray and optical diagnostic tools for pMDI sprays are combined with advanced computer modelling to identify and test new nozzle designs that can be
optimized for use with low GWP propellants.

Original language	English
Title of host publication	Proceedings of Respiratory Drug Delivery 2021
Publisher	Virginia Commonwealth University
Publication status	Published - 4 May 2021
Event	Respiratory Drug Delivery 2021 - Online, United States of America Duration: 4 May 2021 → 7 May 2021 https://www.rddonline.com/rdd/knowledge_space.php?id=20&sessionID=109

Conference

Conference	Respiratory Drug Delivery 2021
Abbreviated title	RDD 2021
Country/Territory	United States of America
Period	4/05/21 → 7/05/21
Internet address	https://www.rddonline.com/rdd/knowledge_space.php?id=20&sessionID=109

Access to Document

Accepted manuscript unformattedAccepted author manuscript, 4.01 MBLicence: Unspecified

Cite this

@inproceedings{11ea3792e88b47e3ace4075ec6cc116f,

title = "Combining modelling with advanced experimental techniques to optimize formulation and nozzle design for low GWP pMDIs",

abstract = "The design of the next generation of pressured metered dose inhalers (pMDIs) will be driven by the transition to low global warming potential (GWP) propellants. One of the major design challenges is the optimization of the actuator nozzle to achieve equivalent or improved outcomes to current generation devices. Thermophysical property changes and a myriad of fluid-mechanical effects complicate the link between formulation and nozzle design. In this paper, using model solution formulations of hydrofluoroalkane 134a (HFA-134a) and HFA-152a propellants, state of the art X-ray and optical diagnostic tools for pMDI sprays are combined with advanced computer modelling to identify and test new nozzle designs that can beoptimized for use with low GWP propellants.",

author = "Duke, {Daniel J.} and Dung Nguyen and Harry Scott and AJ Kusangaya and Kastengren, {Alan L} and David Schmidt and Damon Honnery",

note = "Volume, issue and ISBN data will be updated when the print version goes to press. ; Respiratory Drug Delivery 2021, RDD 2021 ; Conference date: 04-05-2021 Through 07-05-2021",

year = "2021",

month = may,

day = "4",

language = "English",

booktitle = "Proceedings of Respiratory Drug Delivery 2021",

publisher = "Virginia Commonwealth University",

url = "https://www.rddonline.com/rdd/knowledge_space.php?id=20&sessionID=109",

}

TY - GEN

T1 - Combining modelling with advanced experimental techniques to optimize formulation and nozzle design for low GWP pMDIs

AU - Duke, Daniel J.

AU - Nguyen, Dung

AU - Scott, Harry

AU - Kusangaya, AJ

AU - Kastengren, Alan L

AU - Schmidt, David

AU - Honnery, Damon

N1 - Volume, issue and ISBN data will be updated when the print version goes to press.

PY - 2021/5/4

Y1 - 2021/5/4

N2 - The design of the next generation of pressured metered dose inhalers (pMDIs) will be driven by the transition to low global warming potential (GWP) propellants. One of the major design challenges is the optimization of the actuator nozzle to achieve equivalent or improved outcomes to current generation devices. Thermophysical property changes and a myriad of fluid-mechanical effects complicate the link between formulation and nozzle design. In this paper, using model solution formulations of hydrofluoroalkane 134a (HFA-134a) and HFA-152a propellants, state of the art X-ray and optical diagnostic tools for pMDI sprays are combined with advanced computer modelling to identify and test new nozzle designs that can beoptimized for use with low GWP propellants.

AB - The design of the next generation of pressured metered dose inhalers (pMDIs) will be driven by the transition to low global warming potential (GWP) propellants. One of the major design challenges is the optimization of the actuator nozzle to achieve equivalent or improved outcomes to current generation devices. Thermophysical property changes and a myriad of fluid-mechanical effects complicate the link between formulation and nozzle design. In this paper, using model solution formulations of hydrofluoroalkane 134a (HFA-134a) and HFA-152a propellants, state of the art X-ray and optical diagnostic tools for pMDI sprays are combined with advanced computer modelling to identify and test new nozzle designs that can beoptimized for use with low GWP propellants.

M3 - Conference Paper

BT - Proceedings of Respiratory Drug Delivery 2021

PB - Virginia Commonwealth University

T2 - Respiratory Drug Delivery 2021

Y2 - 4 May 2021 through 7 May 2021

ER -