Combined transplantation of GDAsBMP and hr-decorin in spinal cord contusion repair

Liang Wu, Jian Jun Li, Liang Chen, Hong Zhang, Li Yuan, Stephen J.A. Davies

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astro-cytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, double-immunofluorescent histochemistry revealed that combined transplantation inhibited the early inflammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was secreted by transplanted cells, protected injured axons. The combined transplantation promoted axonal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte proli-feration and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels.

Original languageEnglish
Pages (from-to)2236-2248
Number of pages13
JournalNeural Regeneration Research
Volume8
Issue number24
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

Keywords

  • Astrocytes
  • Brain-derived growth factor
  • Combined transplantation
  • Glial cells
  • Glial fibrillary acidic protein
  • Glial progenitor cells
  • Glial scar
  • Grants-supported paper
  • Human recombinant decorin
  • Neural regeneration
  • Neural stem cells
  • Neuroregeneration
  • Spinal cord injury

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