Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIXtm adjuvanted recombinant antigens

Ana Vujanic; Janet Wee; Kenneth Snibson; Stirling Edwards; Martin Pearse; Charles Quinn; Margaret Maloney; Shirley Taylor; Jean-Pierre Scheerlinck; Philip Sutton

doi:10.1016/j.vaccine.2010.01.018

Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIXtm adjuvanted recombinant antigens

Ana Vujanic, Janet Wee, Kenneth Snibson, Stirling Edwards, Martin Pearse, Charles Quinn, Margaret Maloney, Shirley Taylor, Jean-Pierre Scheerlinck, Philip Sutton

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity.

Original language	English
Pages (from-to)	2593 - 2597
Number of pages	5
Journal	Vaccine
Volume	28
Issue number	14
DOIs	https://doi.org/10.1016/j.vaccine.2010.01.018
Publication status	Published - 2010
Externally published	Yes

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title = "Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIXtm adjuvanted recombinant antigens",

abstract = "Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity.",

author = "Ana Vujanic and Janet Wee and Kenneth Snibson and Stirling Edwards and Martin Pearse and Charles Quinn and Margaret Maloney and Shirley Taylor and Jean-Pierre Scheerlinck and Philip Sutton",

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doi = "10.1016/j.vaccine.2010.01.018",

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TY - JOUR

T1 - Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIXtm adjuvanted recombinant antigens

AU - Vujanic, Ana

AU - Wee, Janet

AU - Snibson, Kenneth

AU - Edwards, Stirling

AU - Pearse, Martin

AU - Quinn, Charles

AU - Maloney, Margaret

AU - Taylor, Shirley

AU - Scheerlinck, Jean-Pierre

AU - Sutton, Philip

PY - 2010

Y1 - 2010

N2 - Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity.

AB - Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity.

UR - http://www.sciencedirect.com/science/article/pii/S0264410X10000496

U2 - 10.1016/j.vaccine.2010.01.018

DO - 10.1016/j.vaccine.2010.01.018

M3 - Article

VL - 28

SP - 2593

EP - 2597

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 14

ER -

Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIXtm adjuvanted recombinant antigens

Abstract

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