Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIXtm adjuvanted recombinant antigens

Ana Vujanic, Janet Wee, Kenneth Snibson, Stirling Edwards, Martin Pearse, Charles Quinn, Margaret Maloney, Shirley Taylor, Jean-Pierre Scheerlinck, Philip Sutton

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity.
Original languageEnglish
Pages (from-to)2593 - 2597
Number of pages5
JournalVaccine
Volume28
Issue number14
DOIs
Publication statusPublished - 2010
Externally publishedYes

Cite this