Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial

Sophia Zoungas, B De Galan, Toshiharu Ninomiya, D Grobbee, P Hamet, Simon Heller, Stephen MacMahon, Michel Marre, Bruce Neal, Anushka Patel, M Woodward, J Chalmers

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Abstract

OBJECTIVE: To assess the magnitude and independence of the effects of routine blood pressure lowering and intensive glucose control on clinical outcomes in patients with long-standing type 2 diabetes. RESEARCH DESIGN AND METHODS: This was a multicenter, factorial randomized trial of perindopril-indapamide versus placebo (double-blind comparison) and intensive glucose control with a gliclazide MR-based regimen (target A1C
Original languageEnglish
Pages (from-to)2068 - 2074
Number of pages7
JournalDiabetes Care
Volume32
Issue number11
DOIs
Publication statusPublished - 2009

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