Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

Zhigang Wang; Rong Ma; Li Yan; Xianfeng Chen; Guangyu Zhu

doi:10.1039/c5cc04376j

Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

Zhigang Wang
, Rong Ma
, Li Yan
, Xianfeng Chen
, Guangyu Zhu

Research output: Contribution to journal › Article › Research › peer-review

87 Citations (Scopus)

Abstract

A nanohybrid is assembled by ratiometrically co-loading Pt(iv) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC₅₀ values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.

Original language	English
Pages (from-to)	11587-11590
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	58
DOIs	https://doi.org/10.1039/c5cc04376j
Publication status	Published - 25 Jul 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c5cc04376j

Cite this

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title = "Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance",

abstract = "A nanohybrid is assembled by ratiometrically co-loading Pt(iv) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.",

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AU - Wang, Zhigang

AU - Ma, Rong

AU - Yan, Li

AU - Chen, Xianfeng

AU - Zhu, Guangyu

PY - 2015/7/25

Y1 - 2015/7/25

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AB - A nanohybrid is assembled by ratiometrically co-loading Pt(iv) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.

UR - https://www.scopus.com/pages/publications/84936085429

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DO - 10.1039/c5cc04376j

M3 - Article

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EP - 11590

JO - Chemical Communications

JF - Chemical Communications

IS - 58

ER -

Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

Abstract

UN SDGs

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