Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance

Zhigang Wang, Rong Ma, Li Yan, Xianfeng Chen, Guangyu Zhu

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54 Citations (Scopus)

Abstract

A nanohybrid is assembled by ratiometrically co-loading Pt(iv) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.

Original languageEnglish
Pages (from-to)11587-11590
Number of pages4
JournalChemical Communications
Volume51
Issue number58
DOIs
Publication statusPublished - 25 Jul 2015
Externally publishedYes

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