Abstract
A nanohybrid is assembled by ratiometrically co-loading Pt(iv) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.
Original language | English |
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Pages (from-to) | 11587-11590 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 51 |
Issue number | 58 |
DOIs | |
Publication status | Published - 25 Jul 2015 |
Externally published | Yes |