Combinatorial synthesis of matrix metalloproteinase inhibitors

J. Montana, A. Baxter, S. Shuttleworth, D. Manallack, J. Bird, R. Bhogal, K. Minton, S. Jagpal

Research output: Contribution to journalArticleResearchpeer-review


Combinatorial chemistry has evolved from its early focus as a random strategy for generating molecular diversity into a powerful design technology for discovering and optimizing drug candidates. This paper outlines the application of combinatorial chemistry to lead optimization in its matrix metalloproteinase inhibitor programme.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalInternational Journal of Pharmaceutical Medicine
Issue number1
Publication statusPublished - 1 Jan 1998
Externally publishedYes

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