Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

Nguyen Lam Vuong; Phung Khanh Lam; Damien Keng Yen Ming; Huynh Thi Le Duyen; Nguyet Minh Nguyen; Dong Thi Hoai Tam; Duong Thi Hue Kien; Nguyen Van Vinh Chau; Ngoun Chanpheaktra; Lucy Chai See Lum; Ernesto Pleités; Cameron P. Simmons; Kerstin D. Rosenberger; Thomas Jaenisch; David Bell; Nathalie Acestor; Christine Halleux; Piero L. Olliaro; Bridget A. Wills; Ronald B. Geskus; Sophie Yacoub

doi:10.7554/eLife.67460

Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

Nguyen Lam Vuong, Phung Khanh Lam, Damien Keng Yen Ming, Huynh Thi Le Duyen, Nguyet Minh Nguyen, Dong Thi Hoai Tam, Duong Thi Hue Kien, Nguyen Van Vinh Chau, Ngoun Chanpheaktra, Lucy Chai See Lum, Ernesto Pleités, Cameron P. Simmons, Kerstin D. Rosenberger, Thomas Jaenisch, David Bell, Nathalie Acestor, Christine Halleux, Piero L. Olliaro, Bridget A. Wills, Ronald B. GeskusSophie Yacoub

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of ten biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD). Methods: We performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included. Results: On days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults. Conclusions: Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.

Original language	English
Article number	e67460
Number of pages	41
Journal	eLife
Volume	10
DOIs	https://doi.org/10.7554/eLife.67460
Publication status	Published - Jun 2021

Keywords

Biomarkers
Dengue
IL1Ra
Prognostic
Syndecan

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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352519622-oaFinal published version, 21.2 MBLicence: CC BY

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Vuong, N. L., Lam, P. K., Ming, D. K. Y., Le Duyen, H. T., Nguyen, N. M., Tam, D. T. H., Kien, D. T. H., Chau, N. V. V., Chanpheaktra, N., Lum, L. C. S., Pleités, E., Simmons, C. P., Rosenberger, K. D., Jaenisch, T., Bell, D., Acestor, N., Halleux, C., Olliaro, P. L., Wills, B. A., ... Yacoub, S. (2021). Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes. eLife, 10, [e67460]. https://doi.org/10.7554/eLife.67460

@article{bc731f4ee7fc4a62b788943a1566697b,

title = "Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes",

abstract = "Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of ten biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD). Methods: We performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included. Results: On days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults. Conclusions: Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.",

keywords = "Biomarkers, Dengue, IL1Ra, Prognostic, Syndecan",

author = "Vuong, {Nguyen Lam} and Lam, {Phung Khanh} and Ming, {Damien Keng Yen} and {Le Duyen}, {Huynh Thi} and Nguyen, {Nguyet Minh} and Tam, {Dong Thi Hoai} and Kien, {Duong Thi Hue} and Chau, {Nguyen Van Vinh} and Ngoun Chanpheaktra and Lum, {Lucy Chai See} and Ernesto Pleit{\'e}s and Simmons, {Cameron P.} and Rosenberger, {Kerstin D.} and Thomas Jaenisch and David Bell and Nathalie Acestor and Christine Halleux and Olliaro, {Piero L.} and Wills, {Bridget A.} and Geskus, {Ronald B.} and Sophie Yacoub",

note = "Funding Information: This work was supported by the European Union?s Seventh Framework Programme for research, technological development and demonstration (grant FP7-281803 IDAMS; http://www.idams.eu; publication reference number IDAMS: 53), and by the World Health Organization, UNICEF/UNDP/ World Bank/WHO Special Programme for Research and Training in Tropical Diseases, and by the Bill and Melinda Gates Foundation Trust through The Global Good Fund I, LLC at Intellectual Ventures. The funders had no role in the study design, data collection and analysis, or preparation of the manuscript. The authors alone are responsible for the views expressed in this article and they do not necessarily represent the views, decisions or policies of the institutions with which they are affiliated. Funding Information: This?work?was?supported?by?the?European?Union{\textquoteright}s?Seventh Framework Programme for research, Publisher Copyright: {\textcopyright} 2021, eLife Sciences Publications Ltd. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = jun,

doi = "10.7554/eLife.67460",

language = "English",

volume = "10",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Organisation, Ltd.",

}

Vuong, NL, Lam, PK, Ming, DKY, Le Duyen, HT, Nguyen, NM, Tam, DTH, Kien, DTH, Chau, NVV, Chanpheaktra, N, Lum, LCS, Pleités, E, Simmons, CP, Rosenberger, KD, Jaenisch, T, Bell, D, Acestor, N, Halleux, C, Olliaro, PL, Wills, BA, Geskus, RB & Yacoub, S 2021, 'Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes', eLife, vol. 10, e67460. https://doi.org/10.7554/eLife.67460

TY - JOUR

T1 - Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

AU - Vuong, Nguyen Lam

AU - Lam, Phung Khanh

AU - Ming, Damien Keng Yen

AU - Le Duyen, Huynh Thi

AU - Nguyen, Nguyet Minh

AU - Tam, Dong Thi Hoai

AU - Kien, Duong Thi Hue

AU - Chau, Nguyen Van Vinh

AU - Chanpheaktra, Ngoun

AU - Lum, Lucy Chai See

AU - Pleités, Ernesto

AU - Simmons, Cameron P.

AU - Rosenberger, Kerstin D.

AU - Jaenisch, Thomas

AU - Bell, David

AU - Acestor, Nathalie

AU - Halleux, Christine

AU - Olliaro, Piero L.

AU - Wills, Bridget A.

AU - Geskus, Ronald B.

AU - Yacoub, Sophie

N1 - Funding Information: This work was supported by the European Union?s Seventh Framework Programme for research, technological development and demonstration (grant FP7-281803 IDAMS; http://www.idams.eu; publication reference number IDAMS: 53), and by the World Health Organization, UNICEF/UNDP/ World Bank/WHO Special Programme for Research and Training in Tropical Diseases, and by the Bill and Melinda Gates Foundation Trust through The Global Good Fund I, LLC at Intellectual Ventures. The funders had no role in the study design, data collection and analysis, or preparation of the manuscript. The authors alone are responsible for the views expressed in this article and they do not necessarily represent the views, decisions or policies of the institutions with which they are affiliated. Funding Information: This?work?was?supported?by?the?European?Union’s?Seventh Framework Programme for research, Publisher Copyright: © 2021, eLife Sciences Publications Ltd. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of ten biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD). Methods: We performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included. Results: On days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults. Conclusions: Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.

AB - Background: Early identification of severe dengue patients is important regarding patient management and resource allocation. We investigated the association of ten biomarkers (VCAM-1, SDC-1, Ang-2, IL-8, IP-10, IL-1RA, sCD163, sTREM-1, ferritin, CRP) with the development of severe/moderate dengue (S/MD). Methods: We performed a nested case-control study from a multi-country study. A total of 281 S/MD and 556 uncomplicated dengue cases were included. Results: On days 1-3 from symptom onset, higher levels of any biomarker increased the risk of developing S/MD. When assessing together, SDC-1 and IL-1RA were stable, while IP-10 changed the association from positive to negative; others showed weaker associations. The best combinations associated with S/MD comprised IL-1RA, Ang-2, IL-8, ferritin, IP-10, and SDC-1 for children, and SDC-1, IL-8, ferritin, sTREM-1, IL-1RA, IP-10, and sCD163 for adults. Conclusions: Our findings assist the development of biomarker panels for clinical use and could improve triage and risk prediction in dengue patients.

KW - Biomarkers

KW - Dengue

KW - IL1Ra

KW - Prognostic

KW - Syndecan

UR - http://www.scopus.com/inward/record.url?scp=85109010770&partnerID=8YFLogxK

U2 - 10.7554/eLife.67460

DO - 10.7554/eLife.67460

M3 - Article

C2 - 34154705

AN - SCOPUS:85109010770

VL - 10

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e67460

ER -

Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

Abstract

Keywords

UN SDGs

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