Combating ovarian aging depends on the use of existing ovarian follicles, not on putative oogonial stem cells

Hua Zhang, Deepak Adhikari, Wenjing Zheng, Kui Liu

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Ovarian aging is characterized by both a reduction in egg quality and a drastic reduction in the number of ovarian follicles. It has been generally accepted for 60 years that a fixed population of primordial follicles is established in the ovaries during early life, and in most mammalian species, oocytes cannot renew themselves in postnatal or adult life. This dogma, however, has been challenged over the past decade. In this review, we summarize the recent studies on primordial follicles and putative oogonial stem cells and discuss what resources in the ovary might be more reliable and promising source tools for combating ovarian aging.

Original languageEnglish
JournalReproduction
Volume146
Issue number6
DOIs
Publication statusPublished - Dec 2013
Externally publishedYes

Cite this

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abstract = "Ovarian aging is characterized by both a reduction in egg quality and a drastic reduction in the number of ovarian follicles. It has been generally accepted for 60 years that a fixed population of primordial follicles is established in the ovaries during early life, and in most mammalian species, oocytes cannot renew themselves in postnatal or adult life. This dogma, however, has been challenged over the past decade. In this review, we summarize the recent studies on primordial follicles and putative oogonial stem cells and discuss what resources in the ovary might be more reliable and promising source tools for combating ovarian aging.",
author = "Hua Zhang and Deepak Adhikari and Wenjing Zheng and Kui Liu",
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journal = "Reproduction",
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Combating ovarian aging depends on the use of existing ovarian follicles, not on putative oogonial stem cells. / Zhang, Hua; Adhikari, Deepak; Zheng, Wenjing; Liu, Kui.

In: Reproduction, Vol. 146, No. 6, 12.2013.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Combating ovarian aging depends on the use of existing ovarian follicles, not on putative oogonial stem cells

AU - Zhang, Hua

AU - Adhikari, Deepak

AU - Zheng, Wenjing

AU - Liu, Kui

PY - 2013/12

Y1 - 2013/12

N2 - Ovarian aging is characterized by both a reduction in egg quality and a drastic reduction in the number of ovarian follicles. It has been generally accepted for 60 years that a fixed population of primordial follicles is established in the ovaries during early life, and in most mammalian species, oocytes cannot renew themselves in postnatal or adult life. This dogma, however, has been challenged over the past decade. In this review, we summarize the recent studies on primordial follicles and putative oogonial stem cells and discuss what resources in the ovary might be more reliable and promising source tools for combating ovarian aging.

AB - Ovarian aging is characterized by both a reduction in egg quality and a drastic reduction in the number of ovarian follicles. It has been generally accepted for 60 years that a fixed population of primordial follicles is established in the ovaries during early life, and in most mammalian species, oocytes cannot renew themselves in postnatal or adult life. This dogma, however, has been challenged over the past decade. In this review, we summarize the recent studies on primordial follicles and putative oogonial stem cells and discuss what resources in the ovary might be more reliable and promising source tools for combating ovarian aging.

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U2 - 10.1530/REP-13-0202

DO - 10.1530/REP-13-0202

M3 - Review Article

VL - 146

JO - Reproduction

JF - Reproduction

SN - 1470-1626

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ER -