TY - JOUR
T1 - Colorectal cancer atlas
T2 - An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues
AU - Chisanga, David
AU - Keerthikumar, Shivakumar
AU - Pathan, Mohashin
AU - Ariyaratne, Dinuka
AU - Kalra, Hina
AU - Boukouris, Stephanie
AU - Mathew, Nidhi Abraham
AU - Al Saffar, Haidar
AU - Gangoda, Lahiru
AU - Ang, Ching-Seng
AU - Sieber, Oliver M.
AU - Mariadason, John M.
AU - Dasgupta, Ramanuj
AU - Chilamkurti, Naveen
AU - Mathivanan, Suresh
N1 - Publisher Copyright:
© The Author(s) 2015.
PY - 2016
Y1 - 2016
N2 - In order to advance our understanding of colorectal cancer (CRC) development and progression, biomedical researchers have generated large amounts of OMICS data from CRC patient samples and representative cell lines. However, these data are deposited in various repositories or in supplementary tables. A database which integrates data from heterogeneous resources and enables analysis of the multidimensional data sets, specifically pertaining to CRC is currently lacking. Here, we have developed Colorectal Cancer Atlas (http://www.colonatlas.org), an integrated web-based resource that catalogues the genomic and proteomic annotations identified in CRC tissues and cell lines. The data catalogued to-date include sequence variations as well as quantitative and non-quantitative protein expression data. The database enables the analysis of these data in the context of signaling pathways, protein-protein interactions, Gene Ontology terms, protein domains and post-translational modifications. Currently, Colorectal Cancer Atlas contains data for >13 711 CRC tissues, >165 CRC cell lines, 62 251 protein identifications, >8.3 million MS/MS spectra, >18 410 genes with sequence variations (404 278 entries) and 351 pathways with sequence variants. Overall, Colorectal Cancer Atlas has been designed to serve as a central resource to facilitate research in CRC.
AB - In order to advance our understanding of colorectal cancer (CRC) development and progression, biomedical researchers have generated large amounts of OMICS data from CRC patient samples and representative cell lines. However, these data are deposited in various repositories or in supplementary tables. A database which integrates data from heterogeneous resources and enables analysis of the multidimensional data sets, specifically pertaining to CRC is currently lacking. Here, we have developed Colorectal Cancer Atlas (http://www.colonatlas.org), an integrated web-based resource that catalogues the genomic and proteomic annotations identified in CRC tissues and cell lines. The data catalogued to-date include sequence variations as well as quantitative and non-quantitative protein expression data. The database enables the analysis of these data in the context of signaling pathways, protein-protein interactions, Gene Ontology terms, protein domains and post-translational modifications. Currently, Colorectal Cancer Atlas contains data for >13 711 CRC tissues, >165 CRC cell lines, 62 251 protein identifications, >8.3 million MS/MS spectra, >18 410 genes with sequence variations (404 278 entries) and 351 pathways with sequence variants. Overall, Colorectal Cancer Atlas has been designed to serve as a central resource to facilitate research in CRC.
UR - http://www.scopus.com/inward/record.url?scp=84976870049&partnerID=8YFLogxK
U2 - 10.1093/nar/gkv1097
DO - 10.1093/nar/gkv1097
M3 - Article
C2 - 26496946
AN - SCOPUS:84976870049
SN - 0305-1048
VL - 44
SP - D969-D974
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -
