Colony Stimulating Factors (CSFs)

Andrew J. Fleetwood; Adrian Achuthan; John A. Hamilton

doi:10.1016/B978-0-12-374279-7.10015-3

Colony Stimulating Factors (CSFs)

Andrew J. Fleetwood
, Adrian Achuthan
, John A. Hamilton

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

5 Citations (Scopus)

Abstract

The four colony stimulating factors (CSFs), macrophage-CSF (M-CSF or CSF-1), granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF), and interleukin (IL)-3 (or multi-CSF) were originally defined as hematopoietic growth factors capable of regulating in vitro proliferation, differentiation, and survival of lineage-specific myeloid cells from progenitor cells. They have since been shown to regulate myeloid cell numbers and function at steady state and during inflammation/autoimmunity. Preclinical data suggest that targeting CSFs might be beneficial in autoimmune and inflammatory disease, and manipulation of CSF biology is now being tested in clinical trials in this context. Here, we examine recent insights into CSF function at steady state and during pathology.

Original language	English
Title of host publication	Encyclopedia of Immunobiology
Subtitle of host publication	Molecular Immunology
Editors	Michael J.H. Ratcliffe
Place of Publication	Oxford OX5 UK
Publisher	Academic Press
Pages	586-596
Number of pages	11
Volume	2
ISBN (Print)	9780080921525
DOIs	https://doi.org/10.1016/B978-0-12-374279-7.10015-3
Publication status	Published - 2016
Externally published	Yes

Keywords

Blast colony-forming cells (BL-CFC)
Colony stimulating factor-1 (CSF-1)
Colony stimulating factors (CSFs)
Granulocyte-colony stimulating factor (G-CSF)
Granulocyte/macrophage-colony stimulating factor (GM-CSF)
Hematopoiesis
Immunity
Inflammation
Interleukin-3 (IL-3)
Macrophage-colony stimulating factor (M-CSF)
Myelopoiesis

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10.1016/B978-0-12-374279-7.10015-3

Cite this

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title = "Colony Stimulating Factors (CSFs)",

abstract = "The four colony stimulating factors (CSFs), macrophage-CSF (M-CSF or CSF-1), granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF), and interleukin (IL)-3 (or multi-CSF) were originally defined as hematopoietic growth factors capable of regulating in vitro proliferation, differentiation, and survival of lineage-specific myeloid cells from progenitor cells. They have since been shown to regulate myeloid cell numbers and function at steady state and during inflammation/autoimmunity. Preclinical data suggest that targeting CSFs might be beneficial in autoimmune and inflammatory disease, and manipulation of CSF biology is now being tested in clinical trials in this context. Here, we examine recent insights into CSF function at steady state and during pathology.",

keywords = "Blast colony-forming cells (BL-CFC), Colony stimulating factor-1 (CSF-1), Colony stimulating factors (CSFs), Granulocyte-colony stimulating factor (G-CSF), Granulocyte/macrophage-colony stimulating factor (GM-CSF), Hematopoiesis, Immunity, Inflammation, Interleukin-3 (IL-3), Macrophage-colony stimulating factor (M-CSF), Myelopoiesis",

author = "Fleetwood, \{Andrew J.\} and Adrian Achuthan and Hamilton, \{John A.\}",

year = "2016",

doi = "10.1016/B978-0-12-374279-7.10015-3",

language = "English",

isbn = "9780080921525",

volume = "2",

pages = "586--596",

editor = "Ratcliffe, \{Michael J.H.\}",

booktitle = "Encyclopedia of Immunobiology",

publisher = "Academic Press",

address = "United States of America",

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TY - CHAP

T1 - Colony Stimulating Factors (CSFs)

AU - Fleetwood, Andrew J.

AU - Achuthan, Adrian

AU - Hamilton, John A.

PY - 2016

Y1 - 2016

N2 - The four colony stimulating factors (CSFs), macrophage-CSF (M-CSF or CSF-1), granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF), and interleukin (IL)-3 (or multi-CSF) were originally defined as hematopoietic growth factors capable of regulating in vitro proliferation, differentiation, and survival of lineage-specific myeloid cells from progenitor cells. They have since been shown to regulate myeloid cell numbers and function at steady state and during inflammation/autoimmunity. Preclinical data suggest that targeting CSFs might be beneficial in autoimmune and inflammatory disease, and manipulation of CSF biology is now being tested in clinical trials in this context. Here, we examine recent insights into CSF function at steady state and during pathology.

AB - The four colony stimulating factors (CSFs), macrophage-CSF (M-CSF or CSF-1), granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF), and interleukin (IL)-3 (or multi-CSF) were originally defined as hematopoietic growth factors capable of regulating in vitro proliferation, differentiation, and survival of lineage-specific myeloid cells from progenitor cells. They have since been shown to regulate myeloid cell numbers and function at steady state and during inflammation/autoimmunity. Preclinical data suggest that targeting CSFs might be beneficial in autoimmune and inflammatory disease, and manipulation of CSF biology is now being tested in clinical trials in this context. Here, we examine recent insights into CSF function at steady state and during pathology.

KW - Blast colony-forming cells (BL-CFC)

KW - Colony stimulating factor-1 (CSF-1)

KW - Colony stimulating factors (CSFs)

KW - Granulocyte-colony stimulating factor (G-CSF)

KW - Granulocyte/macrophage-colony stimulating factor (GM-CSF)

KW - Hematopoiesis

KW - Immunity

KW - Inflammation

KW - Interleukin-3 (IL-3)

KW - Macrophage-colony stimulating factor (M-CSF)

KW - Myelopoiesis

UR - https://www.scopus.com/pages/publications/85043258120

U2 - 10.1016/B978-0-12-374279-7.10015-3

DO - 10.1016/B978-0-12-374279-7.10015-3

M3 - Chapter (Book)

AN - SCOPUS:85043258120

SN - 9780080921525

VL - 2

SP - 586

EP - 596

BT - Encyclopedia of Immunobiology

A2 - Ratcliffe, Michael J.H.

PB - Academic Press

CY - Oxford OX5 UK

ER -

Colony Stimulating Factors (CSFs)

Abstract

Keywords

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