TY - JOUR
T1 - Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses
AU - Alikhan, Maliha
AU - Jones, Christina
AU - Williams, Timothy
AU - Beckhouse, Anthony
AU - Fletcher, Anne
AU - Kett, Michelle
AU - Sakkal, Samy
AU - Samuel, Chrishan S
AU - Ramsay, Robert
AU - Deane, James
AU - Wells, Christine
AU - Little, Melissa
AU - Hume, David
AU - Ricardo, Sharon
PY - 2011
Y1 - 2011
N2 - Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney weight and volume and was associated with increased numbers of tissue macrophages. Moreover, CSF-1 promotes postnatal renal repair in mice after ischemia-reperfusion injury by recruiting and influencing macrophages toward a reparative state. CSF-1 treatment rapidly accelerated renal repair with tubular epithelial cell replacement, attenuation of interstitial fibrosis, and functional recovery. Analysis of macrophages from CSF-1-treated kidneys showed increased expression of insulin-like growth factor-1 and anti-inflammatory genes that are known CSF-1 targets. Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury.
AB - Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney weight and volume and was associated with increased numbers of tissue macrophages. Moreover, CSF-1 promotes postnatal renal repair in mice after ischemia-reperfusion injury by recruiting and influencing macrophages toward a reparative state. CSF-1 treatment rapidly accelerated renal repair with tubular epithelial cell replacement, attenuation of interstitial fibrosis, and functional recovery. Analysis of macrophages from CSF-1-treated kidneys showed increased expression of insulin-like growth factor-1 and anti-inflammatory genes that are known CSF-1 targets. Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury.
UR - http://www.ncbi.nlm.nih.gov/pubmed/21762674
UR - https://www.scopus.com/pages/publications/80052836313
U2 - 10.1016/j.ajpath.2011.05.037
DO - 10.1016/j.ajpath.2011.05.037
M3 - Article
SN - 0002-9440
VL - 179
SP - 1243
EP - 1256
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 3
ER -