Colony-stimulating factor-1 promotes kidney growth and repair via alteration of macrophage responses

Maliha Alikhan, Christina Jones, Timothy Williams, Anthony Beckhouse, Anne Fletcher, Michelle Kett, Samy Sakkal, Chrishan S Samuel, Robert Ramsay, James Deane, Christine Wells, Melissa Little, David Hume, Sharon Ricardo

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Abstract

Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney weight and volume and was associated with increased numbers of tissue macrophages. Moreover, CSF-1 promotes postnatal renal repair in mice after ischemia-reperfusion injury by recruiting and influencing macrophages toward a reparative state. CSF-1 treatment rapidly accelerated renal repair with tubular epithelial cell replacement, attenuation of interstitial fibrosis, and functional recovery. Analysis of macrophages from CSF-1-treated kidneys showed increased expression of insulin-like growth factor-1 and anti-inflammatory genes that are known CSF-1 targets. Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury.
Original languageEnglish
Pages (from-to)1243 - 1256
Number of pages14
JournalAmerican Journal of Pathology
Volume179
Issue number3
DOIs
Publication statusPublished - 2011

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