Collagen XVII

Cristina Has, Johannes S. Kern

Research output: Contribution to journalReview ArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Collagen XVII has been identified as having a role in inherited junctional epidermolysis bullosa non-Herlitz (JEB-other, MIM #226650). The role of collagen XVII in both autoimmune and genetic blistering disorders demonstrates its relevance to dermal-epidermal adhesion. Collagen XVII is a major structural component of the hemidesmosome (HD), a highly specialized multiprotein complex that mediates the anchorage of basal epithelial cells to the underlying basement membrane in stratified, pseudostratified, and transitional epithelia. This article examines the genetic and pathological features of collagen XVII.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalDermatologic Clinics
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Keywords

  • Bullous pemphigoid
  • Collagen XVII
  • Dermal-epidermal junction
  • Epidermal adhesion
  • Epidermolysis bullosa

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