TY - JOUR
T1 - Collagen XVII
AU - Has, Cristina
AU - Kern, Johannes S.
N1 - Funding Information:
This work was supported in part by a grant from the German Research Foundation DFG (HA 5663/1-1) to C.H.
PY - 2010/1
Y1 - 2010/1
N2 - Collagen XVII has been identified as having a role in inherited junctional epidermolysis bullosa non-Herlitz (JEB-other, MIM #226650). The role of collagen XVII in both autoimmune and genetic blistering disorders demonstrates its relevance to dermal-epidermal adhesion. Collagen XVII is a major structural component of the hemidesmosome (HD), a highly specialized multiprotein complex that mediates the anchorage of basal epithelial cells to the underlying basement membrane in stratified, pseudostratified, and transitional epithelia. This article examines the genetic and pathological features of collagen XVII.
AB - Collagen XVII has been identified as having a role in inherited junctional epidermolysis bullosa non-Herlitz (JEB-other, MIM #226650). The role of collagen XVII in both autoimmune and genetic blistering disorders demonstrates its relevance to dermal-epidermal adhesion. Collagen XVII is a major structural component of the hemidesmosome (HD), a highly specialized multiprotein complex that mediates the anchorage of basal epithelial cells to the underlying basement membrane in stratified, pseudostratified, and transitional epithelia. This article examines the genetic and pathological features of collagen XVII.
KW - Bullous pemphigoid
KW - Collagen XVII
KW - Dermal-epidermal junction
KW - Epidermal adhesion
KW - Epidermolysis bullosa
UR - http://www.scopus.com/inward/record.url?scp=70450237245&partnerID=8YFLogxK
U2 - 10.1016/j.det.2009.10.007
DO - 10.1016/j.det.2009.10.007
M3 - Review Article
C2 - 19945617
AN - SCOPUS:70450237245
SN - 0733-8635
VL - 28
SP - 61
EP - 66
JO - Dermatologic Clinics
JF - Dermatologic Clinics
IS - 1
ER -