ColistinDose, a mobile app for determining intravenous dosage regimens of colistimethate in critically ill adult patients: Clinician-centered design and development study

Xueliang Hua, Chen Li, Jason M. Pogue, Varun S. Sharma, Ilias Karaiskos, Keith S. Kaye, Brian T. Tsuji, Phillip J. Bergen, Yan Zhu, Jiangning Song, Jian Li

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Determining a suitable dose of intravenous colistimethate is challenging because of complicated pharmacokinetics, confusing terminology, and the potential for renal toxicity. Only recently have reliable pharmacokinetic/pharmacodynamic data and dosing recommendations for intravenous colistimethate become available. Objective: The aim of this work was to develop a clinician-friendly, easy-to-use mobile app incorporating up-to-date dosing recommendations for intravenous colistimethate in critically ill adult patients. Methods: Swift programming language and common libraries were used for the development of an app, ColistinDose, on the iPhone operating system (iOS; Apple Inc). The compatibility among different iOS versions and mobile devices was validated. Dosing calculations were based on equations developed in our recent population pharmacokinetic study. Recommended doses generated by the app were validated by comparison against doses calculated manually using the appropriate equations. Results: ColistinDose provides 3 major functionalities, namely (1) calculation of a loading dose, (2) calculation of a daily dose based on the renal function of the patient (including differing types of renal replacement therapies), and (3) retrieval of historical calculation results. It is freely available at the Apple App Store for iOS (version 9 and above). Calculated doses accurately reflected doses recommended in patients with varying degrees of renal function based on the published equations. ColistinDose performs calculations on a local mobile device (iPhone or iPad) without the need for an internet connection. Conclusions: With its user-friendly interface, ColistinDose provides an accurate and easy-to-use tool for clinicians to calculate dosage regimens of intravenous colistimethate in critically ill patients with varying degrees of renal function. It has significant potential to avoid the prescribing errors and patient safety issues that currently confound the clinical use of colistimethate, thereby optimizing patient treatment.

Original languageEnglish
Article numbere20525
Number of pages9
JournalJMIR mHealth and uHealth
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Colistimethate
  • Colistin
  • Colistin methanesulfonate
  • ColistinDose
  • Continuous renal replacement therapy
  • Intermittent hemodialysis
  • Mobile app
  • Polymyxins
  • Renal function
  • Renal replacement therapy
  • Sustained low-efficiency dialysis

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