Cohort studies of long-term exposure to outdoor particulate matter and risks of cancer: A systematic review and meta-analysis

Pei Yu; Suying Guo; Rongbin Xu; Tingting Ye; Shanshan Li; Malcolm R. Sim; Michael J. Abramson; Yuming Guo

doi:10.1016/j.xinn.2021.100143

Cohort studies of long-term exposure to outdoor particulate matter and risks of cancer: A systematic review and meta-analysis

Pei Yu, Suying Guo, Rongbin Xu, Tingting Ye, Shanshan Li, Malcolm R. Sim, Michael J. Abramson, Yuming Guo

Research output: Contribution to journal › Review Article › Research › peer-review

50 Citations (Scopus)

Abstract

Robust evidence is needed for the hazardous effects of outdoor particulate matter (PM) on mortality and morbidity from all types of cancers. To summarize and meta-analyze the association between PM and cancer, published articles reporting associations between outdoor PM exposure and any type of cancer with individual outcome assessment that provided a risk estimate in cohort studies were identified via systematic searches. Of 3,256 records, 47 studies covering 13 cancer sites (30 for lung cancer, 12 for breast cancer, 11 for other cancers) were included in the quantitative evaluation. The pooled relative risks (RRs) for lung cancer incidence or mortality associated with every 10-μg/m³ PM_2.5 or PM₁₀ were 1.16 (95% confidence interval [CI], 1.10–1.23; I² = 81%) or 1.22 (95% CI, 1.02–1.45; I² = 96%), respectively. Increased but non-significant risks were found for breast cancer. Other cancers were shown to be associated with PM exposure in some studies but not consistently and thus warrant further investigation.

Original language	English
Article number	100143
Number of pages	14
Journal	The Innovation
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.xinn.2021.100143
Publication status	Published - 28 Aug 2021

Keywords

air pollution
cancer
meta-analysis
particulate matter
systematic review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.xinn.2021.100143Licence: CC BY-NC-ND

Cite this

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title = "Cohort studies of long-term exposure to outdoor particulate matter and risks of cancer: A systematic review and meta-analysis",

abstract = "Robust evidence is needed for the hazardous effects of outdoor particulate matter (PM) on mortality and morbidity from all types of cancers. To summarize and meta-analyze the association between PM and cancer, published articles reporting associations between outdoor PM exposure and any type of cancer with individual outcome assessment that provided a risk estimate in cohort studies were identified via systematic searches. Of 3,256 records, 47 studies covering 13 cancer sites (30 for lung cancer, 12 for breast cancer, 11 for other cancers) were included in the quantitative evaluation. The pooled relative risks (RRs) for lung cancer incidence or mortality associated with every 10-μg/m3 PM2.5 or PM10 were 1.16 (95% confidence interval [CI], 1.10–1.23; I2 = 81%) or 1.22 (95% CI, 1.02–1.45; I2 = 96%), respectively. Increased but non-significant risks were found for breast cancer. Other cancers were shown to be associated with PM exposure in some studies but not consistently and thus warrant further investigation.",

keywords = "air pollution, cancer, meta-analysis, particulate matter, systematic review",

author = "Pei Yu and Suying Guo and Rongbin Xu and Tingting Ye and Shanshan Li and Sim, {Malcolm R.} and Abramson, {Michael J.} and Yuming Guo",

note = "Funding Information: M.J.A. holds investigator-initiated grants from Pfizer and Boehringer-Ingelheim for unrelated research. He has undertaken an unrelated consultancy for and received assistance with conference attendance from Sanofi. He has also received a speaker's fee from GSK. All other authors declare no competing interests. Funding Information: P.Y., R.X., and T.Y. were supported by China Scholarship Council funds (number 201906210065 for P.Y., 201806010405 for R.X., and 201906320051 for T.Y.); S.L. by an Early Career Fellowship of the Australian National Health and Medical Research Council (number APP1109193 ); and Y.G. by Career Development Fellowships of the Australian National Health and Medical Research Council (numbers APP1107107 and APP1163693 ). Publisher Copyright: {\textcopyright} 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = aug,

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doi = "10.1016/j.xinn.2021.100143",

language = "English",

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journal = "The Innovation",

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T2 - A systematic review and meta-analysis

AU - Yu, Pei

AU - Guo, Suying

AU - Xu, Rongbin

AU - Ye, Tingting

AU - Li, Shanshan

AU - Sim, Malcolm R.

AU - Abramson, Michael J.

AU - Guo, Yuming

N1 - Funding Information: M.J.A. holds investigator-initiated grants from Pfizer and Boehringer-Ingelheim for unrelated research. He has undertaken an unrelated consultancy for and received assistance with conference attendance from Sanofi. He has also received a speaker's fee from GSK. All other authors declare no competing interests. Funding Information: P.Y., R.X., and T.Y. were supported by China Scholarship Council funds (number 201906210065 for P.Y., 201806010405 for R.X., and 201906320051 for T.Y.); S.L. by an Early Career Fellowship of the Australian National Health and Medical Research Council (number APP1109193 ); and Y.G. by Career Development Fellowships of the Australian National Health and Medical Research Council (numbers APP1107107 and APP1163693 ). Publisher Copyright: © 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/8/28

Y1 - 2021/8/28

N2 - Robust evidence is needed for the hazardous effects of outdoor particulate matter (PM) on mortality and morbidity from all types of cancers. To summarize and meta-analyze the association between PM and cancer, published articles reporting associations between outdoor PM exposure and any type of cancer with individual outcome assessment that provided a risk estimate in cohort studies were identified via systematic searches. Of 3,256 records, 47 studies covering 13 cancer sites (30 for lung cancer, 12 for breast cancer, 11 for other cancers) were included in the quantitative evaluation. The pooled relative risks (RRs) for lung cancer incidence or mortality associated with every 10-μg/m3 PM2.5 or PM10 were 1.16 (95% confidence interval [CI], 1.10–1.23; I2 = 81%) or 1.22 (95% CI, 1.02–1.45; I2 = 96%), respectively. Increased but non-significant risks were found for breast cancer. Other cancers were shown to be associated with PM exposure in some studies but not consistently and thus warrant further investigation.

AB - Robust evidence is needed for the hazardous effects of outdoor particulate matter (PM) on mortality and morbidity from all types of cancers. To summarize and meta-analyze the association between PM and cancer, published articles reporting associations between outdoor PM exposure and any type of cancer with individual outcome assessment that provided a risk estimate in cohort studies were identified via systematic searches. Of 3,256 records, 47 studies covering 13 cancer sites (30 for lung cancer, 12 for breast cancer, 11 for other cancers) were included in the quantitative evaluation. The pooled relative risks (RRs) for lung cancer incidence or mortality associated with every 10-μg/m3 PM2.5 or PM10 were 1.16 (95% confidence interval [CI], 1.10–1.23; I2 = 81%) or 1.22 (95% CI, 1.02–1.45; I2 = 96%), respectively. Increased but non-significant risks were found for breast cancer. Other cancers were shown to be associated with PM exposure in some studies but not consistently and thus warrant further investigation.

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KW - cancer

KW - meta-analysis

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SN - 2666-6758

VL - 2

JO - The Innovation

JF - The Innovation

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M1 - 100143

ER -

Cohort studies of long-term exposure to outdoor particulate matter and risks of cancer: A systematic review and meta-analysis

Abstract

Keywords

UN SDGs

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Other files and links

Improving the assessment of environmental health risks with new technology and novel approaches

Advancing the assessment of environmental impacts on human health

Cite this

Cohort studies of long-term exposure to outdoor particulate matter and risks of cancer: A systematic review and meta-analysis

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Improving the assessment of environmental health risks with new technology and novel approaches

Advancing the assessment of environmental impacts on human health

Cite this