Cohort Profile: The Barwon Infant Study

Peter Vuillermin, Richard Saffery, Katrina J Allen, John B Carlin, Mimi L K Tang, Sarath Ranganathan, David Paul Burgner, Terry Dwyer, Fiona M Collier, Kim Jachno, Peter Sly, Christos Symeonides, Kathleen McCloskey, John Molloy, Michael Forrester, Anne-Louise Ponsonby

Research output: Contribution to journalArticleOtherpeer-review

60 Citations (Scopus)

Abstract

The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years.
Original languageEnglish
Pages (from-to)1148-1160
Number of pages13
JournalInternational Journal of Epidemiology
Volume44
Issue number4
DOIs
Publication statusPublished - 2015

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