Cohort Profile: The Barwon Infant Study

Peter Vuillermin, Richard Saffery, Katrina J Allen, John B Carlin, Mimi L K Tang, Sarath Ranganathan, David Paul Burgner, Terry Dwyer, Fiona M Collier, Kim Jachno, Peter Sly, Christos Symeonides, Kathleen McCloskey, John Molloy, Michael Forrester, Anne-Louise Ponsonby

Research output: Contribution to journalArticleOtherpeer-review

Abstract

The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years.
Original languageEnglish
Pages (from-to)1148-1160
Number of pages13
JournalInternational Journal of Epidemiology
Volume44
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

Vuillermin, P., Saffery, R., Allen, K. J., Carlin, J. B., Tang, M. L. K., Ranganathan, S., ... Ponsonby, A-L. (2015). Cohort Profile: The Barwon Infant Study. International Journal of Epidemiology, 44(4), 1148-1160. https://doi.org/10.1093/ije/dyv026
Vuillermin, Peter ; Saffery, Richard ; Allen, Katrina J ; Carlin, John B ; Tang, Mimi L K ; Ranganathan, Sarath ; Burgner, David Paul ; Dwyer, Terry ; Collier, Fiona M ; Jachno, Kim ; Sly, Peter ; Symeonides, Christos ; McCloskey, Kathleen ; Molloy, John ; Forrester, Michael ; Ponsonby, Anne-Louise. / Cohort Profile: The Barwon Infant Study. In: International Journal of Epidemiology. 2015 ; Vol. 44, No. 4. pp. 1148-1160.
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Vuillermin, P, Saffery, R, Allen, KJ, Carlin, JB, Tang, MLK, Ranganathan, S, Burgner, DP, Dwyer, T, Collier, FM, Jachno, K, Sly, P, Symeonides, C, McCloskey, K, Molloy, J, Forrester, M & Ponsonby, A-L 2015, 'Cohort Profile: The Barwon Infant Study' International Journal of Epidemiology, vol. 44, no. 4, pp. 1148-1160. https://doi.org/10.1093/ije/dyv026

Cohort Profile: The Barwon Infant Study. / Vuillermin, Peter; Saffery, Richard; Allen, Katrina J; Carlin, John B; Tang, Mimi L K; Ranganathan, Sarath; Burgner, David Paul; Dwyer, Terry; Collier, Fiona M; Jachno, Kim; Sly, Peter; Symeonides, Christos; McCloskey, Kathleen; Molloy, John; Forrester, Michael; Ponsonby, Anne-Louise.

In: International Journal of Epidemiology, Vol. 44, No. 4, 2015, p. 1148-1160.

Research output: Contribution to journalArticleOtherpeer-review

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AU - Burgner, David Paul

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AU - Sly, Peter

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AU - Forrester, Michael

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AB - The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years.

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DO - 10.1093/ije/dyv026

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Vuillermin P, Saffery R, Allen KJ, Carlin JB, Tang MLK, Ranganathan S et al. Cohort Profile: The Barwon Infant Study. International Journal of Epidemiology. 2015;44(4):1148-1160. https://doi.org/10.1093/ije/dyv026