Cohort analysis of two multidisciplined adherence intervention programmes for patients on antiretroviral therapy

A. Doxanakis, T. Read, R. Levy, A. Mijch, C. K. Fairley

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The aim was to analyse data from two randomized controlled trials (RCTs) to determine if an adherence intervention programme for antiretroviral therapy (ART) resulted in a reduction in viral load. A cohort analysis of pre- and post-intervention viral loads and CD4 counts using paired analysis was undertaken on participants who received the intervention programme. Analysis was also undertaken on a control group. The intervention participants had an increase in mean CD4 count (450-478, P = 0.26), and a decline in log viral load (2.48-2.36, P = 0.056). The control group had a decline in mean CD4 counts (596-570, P = 0.53), and an increase in log viral load (2.09-2.11, P = 0.78). The use of an adherence intervention programme is associated with a decrease in mean viral load, which is in contrast to the control group that demonstrated an increase in viral load over time.

Original languageEnglish
Pages (from-to)257-259
Number of pages3
JournalInternational Journal of STD and AIDS
Volume17
Issue number4
DOIs
Publication statusPublished - 1 Apr 2006

Keywords

  • Adherence
  • Antiretroviral
  • HIV
  • Intervention

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