@inproceedings{a55ece856d734dcf812e17b3bb2b12c6,
title = "Coherent interaction of optical second harmonic generation in collagen fibrils",
abstract = "We present the first experimental comparison between optical second harmonic generation images and atomic force microscope images in a matrix of nano-scaled collagen fibrils. Substantial variation of forward and backward propagated second harmonic generation radiation is observed in a single collagen fibril and is nicely correlated with the accurately determined thickness from an atomic force microscope. Contradicting to conventional nonlinear optical theory, our result indicates a linear relationship between fibril thickness and forward / backward second harmonic generation ratio. This is the first demonstration of estimating fibril thickness with nanometer precision by a noninvasive optical method.",
keywords = "Atomic force microscope, Nonlinear scattering, Optical interference, Radiation pattern, Three-dimensional microscopy, Type I collagen",
author = "Chu, \{Shi Wei\} and Tai, \{Shih Peng\} and Chan, \{Ming Che\} and Sun, \{Chi Kuang\} and Hsiao, \{I. Ching\} and Lin, \{Chi Hung\} and Chen, \{Yung Chih\} and Lin, \{Bai Ling\}",
year = "2008",
month = mar,
day = "12",
doi = "10.1117/12.761033",
language = "English",
isbn = "9780819470355",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
editor = "Ammasi Periasamy and So, \{Peter T. C.\}",
booktitle = "Multiphoton Microscopy in the Biomedical Sciences VIII",
note = "Multiphoton Microscopy in the Biomedical Sciences VIII ; Conference date: 20-01-2008 Through 22-01-2008",
}