Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation

Claudine Kraan, Darren Robert Hocking, Nellie Georgiou-Karistianis, Sylvia Ann Metcalfe, Alison D Archibald, Joanne Fielding, Julian Norman Trollor, John Lockyer Bradshaw, Jonathan Cohen, Kim Marie Cornish

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures from the Physiological Profile Assessment (Lord et al., 2003 [39]) were conducted in 28 female PM-carriers (mean age: 41.32. ?. 8.03) and 31 female controls with normal FMR1 alleles (mean age: 41.61. ?. 8.3). Multiple regression analyses were conducted to examine the moderating role of CGG-repeat length on the relation between age and postural sway under dual-task interference. In female PM-carriers, our results showed significantly poorer proprioceptive awareness, slower reaction time, and greater postural displacement when performing a concurrent verbal fluency task. Significantly, these findings showed age- and genetically-modulated changes in dual-task postural displacement in the medio-lateral direction in female PM-carriers. These findings highlight the sensitivity of postural control paradigms in identifying early cerebellar postural changes that may act as surrogate markers of future decline in female PM-carriers.
Original languageEnglish
Pages (from-to)329 - 336
Number of pages8
JournalBehavioural Brain Research
Volume253
DOIs
Publication statusPublished - 2013

Cite this

Kraan, Claudine ; Hocking, Darren Robert ; Georgiou-Karistianis, Nellie ; Metcalfe, Sylvia Ann ; Archibald, Alison D ; Fielding, Joanne ; Trollor, Julian Norman ; Bradshaw, John Lockyer ; Cohen, Jonathan ; Cornish, Kim Marie. / Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation. In: Behavioural Brain Research. 2013 ; Vol. 253. pp. 329 - 336.
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title = "Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation",
abstract = "Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures from the Physiological Profile Assessment (Lord et al., 2003 [39]) were conducted in 28 female PM-carriers (mean age: 41.32. ?. 8.03) and 31 female controls with normal FMR1 alleles (mean age: 41.61. ?. 8.3). Multiple regression analyses were conducted to examine the moderating role of CGG-repeat length on the relation between age and postural sway under dual-task interference. In female PM-carriers, our results showed significantly poorer proprioceptive awareness, slower reaction time, and greater postural displacement when performing a concurrent verbal fluency task. Significantly, these findings showed age- and genetically-modulated changes in dual-task postural displacement in the medio-lateral direction in female PM-carriers. These findings highlight the sensitivity of postural control paradigms in identifying early cerebellar postural changes that may act as surrogate markers of future decline in female PM-carriers.",
author = "Claudine Kraan and Hocking, {Darren Robert} and Nellie Georgiou-Karistianis and Metcalfe, {Sylvia Ann} and Archibald, {Alison D} and Joanne Fielding and Trollor, {Julian Norman} and Bradshaw, {John Lockyer} and Jonathan Cohen and Cornish, {Kim Marie}",
year = "2013",
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language = "English",
volume = "253",
pages = "329 -- 336",
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Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation. / Kraan, Claudine; Hocking, Darren Robert; Georgiou-Karistianis, Nellie; Metcalfe, Sylvia Ann; Archibald, Alison D; Fielding, Joanne; Trollor, Julian Norman; Bradshaw, John Lockyer; Cohen, Jonathan; Cornish, Kim Marie.

In: Behavioural Brain Research, Vol. 253, 2013, p. 329 - 336.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Kraan, Claudine

AU - Hocking, Darren Robert

AU - Georgiou-Karistianis, Nellie

AU - Metcalfe, Sylvia Ann

AU - Archibald, Alison D

AU - Fielding, Joanne

AU - Trollor, Julian Norman

AU - Bradshaw, John Lockyer

AU - Cohen, Jonathan

AU - Cornish, Kim Marie

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