TY - JOUR
T1 - Cognitive assessment during the phases of a spontaneous migraine
T2 - a prospective cohort study
AU - Ray, Jason C.
AU - Darby, David
AU - Butzkueven, Helmut
AU - Matharu, Manjit S.
AU - Hutton, Elspeth J.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/9
Y1 - 2024/9
N2 - Introduction: Cognitive symptoms are reported commonly throughout all phases of a migraine; however, there is a paucity of objective cognitive profiling. Previous studies have been limited by practice effect, and variable populations. Methods: Participants completed 1 month of daily testing with a computerised cognitive battery involving a simple reaction (SRT), choice reaction (CRT) and a working memory test (WM). Results were correlated with their diary to identify interictal scores, and scores during each phase of a migraine, and non-migraine headache days. Results: A total of 16 patients with episodic migraine participated. During the headache phase of a migraine, responses to SRT, CRT and WM tasks were significantly slower and less accurate than interictally. During the postdrome, WM task performance was slower and less accurate. Non-migraine headache days were not associated with significant change. Conclusion: The headache and postdromal phase of a migraine day was associated with objective evidence of cognitive dysfunction in patients with episodic migraine.
AB - Introduction: Cognitive symptoms are reported commonly throughout all phases of a migraine; however, there is a paucity of objective cognitive profiling. Previous studies have been limited by practice effect, and variable populations. Methods: Participants completed 1 month of daily testing with a computerised cognitive battery involving a simple reaction (SRT), choice reaction (CRT) and a working memory test (WM). Results were correlated with their diary to identify interictal scores, and scores during each phase of a migraine, and non-migraine headache days. Results: A total of 16 patients with episodic migraine participated. During the headache phase of a migraine, responses to SRT, CRT and WM tasks were significantly slower and less accurate than interictally. During the postdrome, WM task performance was slower and less accurate. Non-migraine headache days were not associated with significant change. Conclusion: The headache and postdromal phase of a migraine day was associated with objective evidence of cognitive dysfunction in patients with episodic migraine.
KW - Cognition
KW - Cognitive impairment
KW - Headache disorders
KW - Migraine
UR - http://www.scopus.com/inward/record.url?scp=85190133053&partnerID=8YFLogxK
U2 - 10.1007/s10072-024-07520-w
DO - 10.1007/s10072-024-07520-w
M3 - Article
C2 - 38607534
AN - SCOPUS:85190133053
SN - 1590-1874
VL - 45
SP - 4445
EP - 4449
JO - Neurological Sciences
JF - Neurological Sciences
IS - 9
ER -
